From: Roles of the intestinal microbiota and microbial metabolites in acute GVHD
Patients | Results | Microbiota analysis methods | References |
---|---|---|---|
Human/Mouse 18 adult patients | Loss of flora diversity was associated with GVHD in humans and mice | 16S rRNA sequencing | [18] |
Mouse | Diversity of the microbiota was significantly reduced in mice with GVHD | 16S rRNA sequencing | [22] |
Human 80 adult patients | Low intestinal microbiota diversity was associated with high TRM, lower OS, and GVHD-related mortality | 16S rRNA sequencing | [23] |
Human 64 adult patients | Increased bacterial diversity was linked to reduced aGVHD-related mortality | 16S rRNA sequencing | [26] |
Human 57 adult recipients and 22 paired adult donors | Recipients with lower diversity had a higher mortality; higher bacterial donor diversity was associated with lower risk of the acute GI GvHD | 16S rRNA sequencing | [24] |
Human 96 adult patients | Low bacterial α-diversity at 10 days after transplantation was significantly correlated with an increased risk of aGvHD | 16S rRNA sequencing | [27] |
Human 66 adult patients | Lower α-diversity of the stool microbiota was associated with aGVHD | 16S rRNA sequencing | [28] |
Human 81 adult patients | aGVHD patients had lower microbial diversity than non-aGVHD patients | 16S rRNA sequencing | [29] |
Human 141 adult patients | Microbial diversity was lower in aGVHD group than non-aGVHD group | 16S rRNA sequencing | [21] |
Human 10 pediatric patients | Gut microbial diversity showed a downward trend in children with GVHD | 16S rRNA sequencing | [30] |
Human 44 adult patients | Microbial diversity was associated with increased incidence of acute GI GVHD. Fecal butyrate and indole levels were correlated with microbial diversity | 16S rRNA sequencing | [31] |
Human 1362 adult patients | Lower diversity was associated with higher GVHD-related mortality | 16S rRNA sequencing | [20] |
Human 70 adult patients | Bacterial biomass and α-diversity were lower in severe aGVHD | 16S rRNA sequencing | [32] |
Human 150 adult patients | Low diversity was associated with high risk of aGVHD | shotgun metagenomic sequencing | [33] |
Human 100 adult patients | Low α-diversity was significantly associated to increased risk of grade II-IV and III-IV acute GvHD | 16S rRNA sequencing | [19] |
Human 56 pediatric patients | Gut microbial diversity was lowest in GI aGVHD patients, which was consistent with higher mortality | 16S rRNA sequencing | [34] |