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Table 1 Loss of intestinal microbial diversity is associated with aGVHD

From: Roles of the intestinal microbiota and microbial metabolites in acute GVHD

Patients

Results

Microbiota analysis methods

References

Human/Mouse 18 adult patients

Loss of flora diversity was associated with GVHD in humans and mice

16S rRNA sequencing

[18]

Mouse

Diversity of the microbiota was significantly reduced in mice with GVHD

16S rRNA sequencing

[22]

Human 80 adult patients

Low intestinal microbiota diversity was associated with high TRM, lower OS, and GVHD-related mortality

16S rRNA sequencing

[23]

Human 64 adult patients

Increased bacterial diversity was linked to reduced aGVHD-related mortality

16S rRNA sequencing

[26]

Human 57 adult recipients and 22 paired adult donors

Recipients with lower diversity had a higher mortality; higher bacterial donor diversity was associated with lower risk of the acute GI GvHD

16S rRNA sequencing

[24]

Human 96 adult patients

Low bacterial α-diversity at 10 days after transplantation was significantly correlated with an increased risk of aGvHD

16S rRNA sequencing

[27]

Human 66 adult patients

Lower α-diversity of the stool microbiota was associated with aGVHD

16S rRNA sequencing

[28]

Human 81 adult patients

aGVHD patients had lower microbial diversity than non-aGVHD patients

16S rRNA sequencing

[29]

Human 141 adult patients

Microbial diversity was lower in aGVHD group than non-aGVHD group

16S rRNA sequencing

[21]

Human 10 pediatric patients

Gut microbial diversity showed a downward trend in children with GVHD

16S rRNA sequencing

[30]

Human 44 adult patients

Microbial diversity was associated with increased incidence of acute GI GVHD. Fecal butyrate and indole levels were correlated with microbial diversity

16S rRNA sequencing

[31]

Human 1362 adult patients

Lower diversity was associated with higher GVHD-related mortality

16S rRNA sequencing

[20]

Human 70 adult patients

Bacterial biomass and α-diversity were lower in severe aGVHD

16S rRNA sequencing

[32]

Human 150 adult patients

Low diversity was associated with high risk of aGVHD

shotgun metagenomic sequencing

[33]

Human 100 adult patients

Low α-diversity was significantly associated to increased risk of grade II-IV and III-IV acute GvHD

16S rRNA sequencing

[19]

Human 56 pediatric patients

Gut microbial diversity was lowest in GI aGVHD patients, which was consistent with higher mortality

16S rRNA sequencing

[34]