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Table 2 Initial treatment, salvage therapy and outcome of 6 R/R ALAL-NOS patients

From: Efficacy of combination of venetoclax with azacitidine or chemotherapy in refractory/relapse acute leukemias of ambiguous lineage, not otherwise specified

No.

Previous treatment

Reinduction treatment

VEN dose, (mg)

VEN days

Response to VEN combination

HSCT

Outcome

OS(m)

1

Chemotherapy and HSCT

VEN + AZA

400 mg

28d

CR

N

Dead

36

2

VDCP NR; DAC + HACVP NR

VEN + AAVP

400 mg

14d

CR

Y

CR

15

3

VDCP NR; DAC + HACVP NR

VEN + AAVP PR; DAC + VEN + AAVP

400 mg

21d

CR

Y

Dead

9

4

DAC + AAVP NR

VEN + HOAP

200 mg

(with voriconazole)

14d

CRi

Y

CR

8

5

VDCP + AA NR

VEN + CA

400 mg

14d

CR

Y

CR

7

6

AACVP NR

VEN + HOAP

400 mg

14d

CR

Y

CR

5

  1. VEN, venetoclax; DAC, decitabine; AZA, azacitidine; VCR, vincristine; DNR, daunorubincin; CTX, cyclophosphamide; Pred, prednisone; HHT, homoharringtonine; Ara-c, cytarabine; Acla, aclarubicin. VDCP:VCR + DNR + CTX + Pred; HACVP, HHT + Ara-c + CTX + VCR + Pred; AAVP, Ac,a + Ara-c + VCR + Pred; AA, Acla + Ara-c; CA cladribine + LDAC; AACVP, Acla + Ara-c + CTX + VCR + Pred; HOAP: HHT + Ara-c + VCR + Pred; HSCT, hematopoietic stem cell transplantation