Table 7 Risk features of myelofibrosis in MDS patients underwent HSCT by Cox regression analysis (n = 141)

Age

0.988

–

0.169

–

0.21

–

0.21

–

1.00 (0.96–1.04)

1.02 (0.99–1.05)

1.02 (0.99–1.04)

1.02 (0.99–1.04)

Sex

–

–

–

–

 Male

Ref.

Ref.

Ref.

Ref.

 Female

0.566

0.304

0.245

0.319

0.76 (0.30–1.93)

0.70 (0.36–1.38)

0.72 (0.42–1.25)

0.74 (0.41–1.34)

Cytogenetics

 Non–complex karyotypes

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Complex karyotypes

0.012

0.006

0.328

0.347

0.012

0.020

0.014

0.009

3.51 (1.32–9.34)

4.16 (1.51–11.45)

1.51 (0.66–3.46)

1.51 (0.64–3.55)

2.24 (1.19–4.20)

2.16 (1.13–4.12)

2.28 (1.18–4.42)

2.47 (1.25–4.90)

BM blasts at HSCT

  ≤ 5%

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

  > 5%

0.349

0.253

0.343

0.245

0.782

0.773

0.763

0.73

1.80 (0.53–6.20)

2.08 (0.59–7.31)

0.72 (0.36–1.43)

0.66 (0.33–1.33)

0.92 (0.51–1.66)

0.92 (0.51–1.66)

0.91 (0.48–1.72)

0.89 (0.47–1.69)

Myelofibrosis

 MF = 0/1

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 MF = 2/3

0.964

0.914

0.986

0.286

0.459

0.396

0.569

0.444

0.97 (0.28–3.34)

1.07 (0.31–3.76)

1.02 (0.13–8.15)

0.56 (0.20–1.62)

0.74 (0.34–1.64)

0.71 (0.32–1.58)

0.78 (0.33–1.84)

0.71 (0.30–1.70)

Time to HSCT from diagnosis

  ≤ 6 months

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

  > 6 months

0.77

0.888

0.56

0.709

0.952

0.678

0.741

0.526

0.86 (0.31–2.39)

1.08 (0.38–3.08)

0.63 (0.13–3.02)

1.15 (0.56–2.34)

1.02 (0.58–1.80)

1.13 (0.63–2.04)

1.11 (0.60–2.04)

1.23 (0.65–2.31)

Previous therapy for MDS

 No cytoreductive treatments

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

Ref.

 Cytoreductive treatments

0.468

0.327

0.337

0.642

0.902

0.856

0.794

0.627

1.41 (0.56–3.60)

1.61 (0.62–4.19)

1.97 (0.49–7.89)

0.86 (0.45–1.64)

0.97 (0.57–1.63)

1.05 (0.62–1.79)

1.08 (0.61–1.91)

1.16 (0.64–2.07)

Donor source

 HID

Ref

–

Ref

–

Ref

–

Ref

–

 MUD

0.806

0.277

0.709

0.903

0.77 (0.09–6.50)

2.49 (0.48–12.81)

0.82 (0.28–2.37)

1.07 (0.37–3.13)

 MSD

0.393

0.374

0.646

0.717

1.54 (0.57–4.11)

0.48 (0.09–2.45)

0.88 (0.51–1.51)

0.90 (0.50–1.62)

Stem cell source

 PB

Ref

–

Ref

–

Ref

–

Ref

–

 PB + BM

0.325

0.628

0.899

0.666

1.60 (0.63–4.07)

0.85 (0.45–1.62)

1.03 (0.61–1.74)

1.13 (0.64–2.00)