Fig. 2
From: Leukemia stem cell-bone marrow microenvironment interplay in acute myeloid leukemia development
Strategies to target the bone marrow microenvironment in AML. AML acute myeloid leukemia, EC endothelial cell, CXCL12 C-X-C motif chemokine 12, CXCR4 C-X-C chemokine receptor 4, VLA-4 very late antigen 4, VCAM-1 vascular cell adhesion molecule 1, VEGF vascular endothelial growth factor, VEGFR vascular endothelial growth factor receptor, LSC leukemic stem cell, CAR cell CXCL12-abundant reticular cell, FN fibronectin, BCL-2 B-cell lymphoma-2