Table 1 Amsterdam criteria II

At least three relatives must have a Lynch syndrome-associated cancer (colorectal, endometrial, small bowel, ureter, or renal pelvic cancer); all of the following criteria should be met:

1. One must be a first-degree relative of the other two

2. At least two successive generations must be affected

3. At least one should have been diagnosed before the age of 50 years

4. Familial adenomatous polyposis should be excluded

5. Tumor diagnosis should be confirmed by histopathological examination