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Fig. 4 | Experimental Hematology & Oncology

Fig. 4

From: Blocking siglec-10hi tumor-associated macrophages improves anti-tumor immunity and enhances immunotherapy for hepatocellular carcinoma

Fig. 4

Intratumoral Siglec-10hi TAMs exhibit mixed M1/M2 phenotype and immunosuppressive function. a Representative flow cytometry histograms showed CD11b, CD206, CD80, CD86 and HLA-DR expression in Siglec-10hi and Siglec-10lo TAMs in HCC tissues. TAMs were pre-gated on CD45 and CD68. b Statistical analysis of CD11b, CD206, CD80, CD86 and HLA-DR expression in Siglec-10hi and Siglec-10lo TAMs in fresh human HCC specimens. Data were analyzed with paired Student’s t-test. c Representative flow cytometry histograms showed the expression of immune inhibitory molecules in Siglec-10hi and Siglec-10lo TAMs. TAMs were pre-gated on CD45 and CD68. d Statistical analysis of immune inhibitory molecules expression in Siglec-10hi and Siglec-10lo TAMs. Data were analyzed with paired Student’s t-test. e Representative flow cytometry histograms showed the expression of pro-inflammatory cytokines in Siglec-10hi and Siglec-10lo TAMs. TAMs were pre-gated on CD45 and CD68. f Statistical analysis of pro-inflammatory cytokines expression in Siglec-10hi and Siglec-10lo TAMs. Data were analyzed using Student’s t-test

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