Skip to main content
Fig. 4 | Experimental Hematology & Oncology

Fig. 4

From: Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4

Fig. 4

BM-MSC-exos promoted leukemia cell invasion via upregulation of S100A4. a BM-MSC-exo treatment significantly upregulated S100A4 expression in leukemia cells. b Western blotting verified the upregulation of the S100A4 protein upon exosome treatment. The knockdown efficiency was evaluated by both qRT-PCR (c) and western blot (d) analyses. S100A4 knockdown attenuated the migration (e) and invasion (f) of leukemia cells induced by BM-MSC-exos. Scale bar for the migration groups (KASUMI-1 and THP-1): 200 μm. Scale bar for the invasion group (KASUMI-1): 100 μm. Scale bar for the invasion group (THP-1): 200 μm. Data are the means ± SD (n = 3; *P < 0.05; n.s., not significant)

Back to article page

Experimental Hematology & Oncology

ISSN: 2162-3619

Contact us