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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: Exosomes from BM-MSCs promote acute myeloid leukemia cell proliferation, invasion and chemoresistance via upregulation of S100A4

Fig. 3

BM-MSC-exos increased the stemness and chemoresistance of leukemia cells. a-d Leukemia cells were cocultured with BM-MSC-exos or treated with PBS, and the CD34 (a,b) and CD123 (c,d) cell populations were determined. e–h Colony formation assays showed that the cell colony forming ability was enhanced upon coculture with BM-MSC-exos. i, j The expression of stemness genes (OCT4, BMI1, KLF4, NANOG and SOX2) in leukemia cells (KASUMI-1 (i) and THP-1 (j)) was increased upon treatment with BM-MSC-exos. k Drug resistance assay. Leukemia cells (THP-1) were treated with different concentrations of Ara-C with or without BM-MSC-exos. Data are the means ± SD (n = 3; *P < 0.05; n.s., not significant; cells cultured with BM-MSC-exos vs. cells cultured with PBS; Student’s t-test)

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Experimental Hematology & Oncology

ISSN: 2162-3619

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