Fig. 5
From: PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma
The FASN/Bax/Bcl-2/Caspase9/Caspase3 pathway is involved in the regulation of PCSK9 on HCC cell apoptosis. a Western blot images and summarized data showing that FASN is overexpressed in the HCCLM3-PCSK9 cell line compared with its control group (p = 0.001). b Western blot images and summarized data showing that FASN is downregulated in the HepG2-shPCSK9 cell line compared with its control group (p < 0.001). c The Bax/Bcl-2/Caspase9/Caspase3 apoptosis signaling pathway-associated proteins were detected by Western blot in HCCLM3-PCSK9 cells and controls. d The Bax/Bcl-2/Caspase9/Caspase3 apoptotic signaling pathway-associated proteins were detected by Western blot in HepG2-shPCSK9 cells and controls. e Specifically blocking FASN with C75 altered the expression of Bax/Bcl-2/Caspase9/Caspase3 apoptotic signaling pathway-associated proteins in the HCCLM3-PCSK9 cell line. *p < 0.05, **p < 0.01, ***p < 0.001