Fig. 3
From: PCSK9 promotes tumor growth by inhibiting tumor cell apoptosis in hepatocellular carcinoma
PCSK9 inhibited apoptosis and promoted the proliferation of HCC cells in vitro. a CCK8 assay for cell proliferation of HCCLM3-PCSK9 cells and HepG2-shPCSK9 cells compared with their vector control. PCSK9 promoted HCC cell proliferation. b Clone formation and summarized data for HCCLM3-PCSK9 cells (p = 0.005) and HepG2-shPCSK9 cells (p = 0.001) compared with their vector controls. PCSK9 promoted clone formation. c Flow cytometry detection of the cell cycle distribution of HCCLM3-PCSK9 cells and HepG2-shPCSK9 cells compared with their vector controls. PCSK9 had no significant influence on the G2/M phase in cell cycle distribution (p > 0.05). d Flow cytometry apoptosis detection to determine the cell apoptosis rates of HCCLM3-PCSK9 cells (p < 0.001) and HepG2-shPCSK9 cells (p < 0.001) compared with their vector controls. PCSK9 decreased the apoptosis rate of HCC cells in vitro. **p < 0.01, ***p < 0.001