Fig. 1
From: VEXAS syndrome in myelodysplastic syndrome with autoimmune disorder
The mutational profile of myelodysplastic syndromes (MDS) patients with autoimmune disorders (AD) and the mutant site and bone marrow aspirate smears of the patient who had a UBA1 mutation.a Mean numbers of gene mutations (showed by mean and SD) and b mutational profile in MDS patients with and without AD. c Chromatograms of UBA1 somatic variant detected in one MDS patient. d The representative bone marrow aspirate smears of the patient with UBA1 mutation showing dysplasia and characteristic cytoplasmic vacuolation of myeloid and erythroid precursors. The black arrows point to common dysplasia including nuclear abnormalities of erythroid precursor cells and the multinucleated micro-megakaryocyte. The red arrows point to cytoplasmic vacuolation of myeloid and erythroid precursors