Fig. 1
From: Targeting phosphoinositide 3-kinases and histone deacetylases in multiple myeloma
Expression of Akt and HDACs in the myeloma cells. a, b U266 cells were co-cultured with or without HS-5 cell culture supernatant and treated with carfilzomib (10 nM) for 48 or 72 h. Percentage cell growth (a) and Akt activity (b) were determined. *P < 0.05 vs. control or HS-5 supernatant treatment group. c Gene expression data were analyzed. Validation of HDAC genes by GEO data (GSE13591) in the normal group (n = 5), MGUS group (n = 11), myeloma group (n = 133), and PCL group (n = 9). *P < 0.05, **P < 0.01 vs. control. d Correlation between RELA, BCL2L1, and MCL1 with HDAC1 or PIK3CA in the myeloma samples by GEO data (GSE13591). The myeloma group was analyzed.