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Table 3 Clinical characteristic and outcomes of patients with NPM1 mutation or fusion genes in FLT3-ITD AML

From: Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Characteristics FLT3-ITD + 
NPM1 + Fusion −
FLT3-ITD + 
Fusion + NPM1 −
P valuea
n 31 24  
Age, years
Median(range)
52 (14–76) 36 (12–65) 0.007
Male
n (%)
12 (38.7) 11 (45.8) 0.254
WBC at diagnosis, × 109/L
Median(range)
31.4 (1.3–405.1) 10.8 (0.7–306.9) 0.278
Blast in BM, %
Median(range)
68.8 (21.2–96.4) 56.4 (11.2–95.6) 0.543
FAB subtype    0.671
 M0 0 (0) 0 (0)  
 M1 1 (3.3) 1 (4.2)  
 M2 8 (26.7) 8 (33.3)  
 M4 13 (43.3) 9 (37.5)  
 M5 6 (20.0) 5 (20.8)  
 M6 0 (0) 1 (4.2)  
 Unclassified 0 (0) 0 (0)  
 Secondary-AML 2 (6.7) 0 (0)  
Karyotype    0.015
Favorable 0 (0) 7 (29.2)  
Intermediate 27 (87.1) 13 (54.2)  
 Normal 22 (71) 9 (37.5) 0.007
 Others 5 (16.1) 4 (16.7)  
Unfavorable 2 (6.5) 3 (12.5)  
Failed 2 (6.5) 1 (4.2)  
Immunophenotype    
 CD34 +  18/25 (72.0) 20/22 (90.9) 0.203
 CD13 +  25/26 (96.3) 18/20 (90.0) 0.814
 CD33 +  26/26 (100) 21/22 (95.5) 0.458
 CD117 +  23/25 (92) 21/22 (95.5) 1.000
 CD64 +  10/24 (41.7) 5/11 (45.5) 1.000
Mutations    
 Average num 3.6 2.2 0.000
 DNMT3A 13/28 (46.4) 2/22 (9.1) 0.004
 Methylation-related genesb 16/28 (57.1) 4/22 (18.2) 0.005
CR, n (%)    
 Yes 14/25 (56) 17/24 (70.8) 0.282
Relapse in 1 year    
 Yes 16/22 (72.7) 17/20 (85) 0.460
  1. Italic values indicate significance of P value (P < 0.05)
  2. WBC white blood count, BM bone marrow, FAB French–America–British, CR complete remission
  3. aP-values for categorical variables are from chi-square test, P-values for continuous variables are from the Mann–Whitney test and Fisher exact test
  4. bMethylation-related genes included DNMT3A, IDH1/2, and TET2