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Table 3 Clinical characteristic and outcomes of patients with NPM1 mutation or fusion genes in FLT3-ITD AML

From: Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Characteristics

FLT3-ITD + 

NPM1 + Fusion −

FLT3-ITD + 

Fusion + NPM1 −

P valuea

n

31

24

 

Age, years

Median(range)

52 (14–76)

36 (12–65)

0.007

Male

n (%)

12 (38.7)

11 (45.8)

0.254

WBC at diagnosis, × 109/L

Median(range)

31.4 (1.3–405.1)

10.8 (0.7–306.9)

0.278

Blast in BM, %

Median(range)

68.8 (21.2–96.4)

56.4 (11.2–95.6)

0.543

FAB subtype

  

0.671

 M0

0 (0)

0 (0)

 

 M1

1 (3.3)

1 (4.2)

 

 M2

8 (26.7)

8 (33.3)

 

 M4

13 (43.3)

9 (37.5)

 

 M5

6 (20.0)

5 (20.8)

 

 M6

0 (0)

1 (4.2)

 

 Unclassified

0 (0)

0 (0)

 

 Secondary-AML

2 (6.7)

0 (0)

 

Karyotype

  

0.015

Favorable

0 (0)

7 (29.2)

 

Intermediate

27 (87.1)

13 (54.2)

 

 Normal

22 (71)

9 (37.5)

0.007

 Others

5 (16.1)

4 (16.7)

 

Unfavorable

2 (6.5)

3 (12.5)

 

Failed

2 (6.5)

1 (4.2)

 

Immunophenotype

   

 CD34 + 

18/25 (72.0)

20/22 (90.9)

0.203

 CD13 + 

25/26 (96.3)

18/20 (90.0)

0.814

 CD33 + 

26/26 (100)

21/22 (95.5)

0.458

 CD117 + 

23/25 (92)

21/22 (95.5)

1.000

 CD64 + 

10/24 (41.7)

5/11 (45.5)

1.000

Mutations

   

 Average num

3.6

2.2

0.000

 DNMT3A

13/28 (46.4)

2/22 (9.1)

0.004

 Methylation-related genesb

16/28 (57.1)

4/22 (18.2)

0.005

CR, n (%)

   

 Yes

14/25 (56)

17/24 (70.8)

0.282

Relapse in 1 year

   

 Yes

16/22 (72.7)

17/20 (85)

0.460

  1. Italic values indicate significance of P value (P < 0.05)
  2. WBC white blood count, BM bone marrow, FAB French–America–British, CR complete remission
  3. aP-values for categorical variables are from chi-square test, P-values for continuous variables are from the Mann–Whitney test and Fisher exact test
  4. bMethylation-related genes included DNMT3A, IDH1/2, and TET2