Table 2 Fusion genes by NGS and PCR and Chromosome karyotype analysis in FLT3 mutant AML
Fusion gene by NGS | Fusion gene by PCR | Chromosome karyotype | FLT3 mutation |
|---|---|---|---|
AML1/ETO | AML1/ETO | 46, XY, t(8;21)(q22;q22)[20] | FLT3-ITD, FLT3-TKD |
AML1/ETO | AML1/ETO | 46, X, -X,t(8;21)(q22;q22), del(9)(q22)[9]/46,XX,t(8;21)(q22;q22)[11] | FLT3-ITD |
AML1/ETO | AML1/ETO | 45, X, -X,t(8;21)[20] | FLT3-ITD |
MLL-PTD | MLL-PTD | 46, XY[20] | FLT3-ITD |
MLL-PTD | MLL-PTD | 46, XY[20] | FLT3-ITD |
MLL-PTD | MLL-PTD | 46, XX[20] | FLT3-ITD |
MLL-PTD | MLL-PTD | 47, XY, + 8?[10]/46, XY[10] | FLT3-ITD |
MLL/AF9 | MLL/AF9 | 46, XX,?der(2)(q11),inc[1] /46,XX[28]/hypodiploid [4] (44–45) | FLT3-ITD |
MLL/AF9 | MLL/AF9 | 47, XY, + 8[7] | FLT3-ITD |
MLL/ELL | MLL/ELL | 46, XX, t(11;19)(q23; q13)[10] | FLT3-ITD |
NUP98/HOXA9 | NUP98/HOXA9 | NA | FLT3-ITD |
NUP98/HOXA9 | NUP98/HOXA9 | 46, XX[20] | FLT3-ITD |
NUP98/HOXA9 | NUP98/HOXA9 | NA | FLT3-ITD |
NUP98-NSD1 | – | 46, XX[20] | FLT3-ITD |
NUP98-NSD1 | – | 47, XX, + 6[14]/46, XX[6] | FLT3-ITD |
NUP98-NSD1 | – | 46, XY[20] | FLT3-ITD |
NUP98-NSD1 | – | 46, XY[25] | FLT3-ITD |
DEK/CAN | DEK/CAN | 46, XX[20] | FLT3-ITD |
DEK/CAN | DEK/CAN | 46, XY, ?t(6;9)(p23;34)[10]/46, XY,?t(6;9)(p23;q34),?del(8)(q21)[11]/46,XY[1] | FLT3-ITD |
PRDM16-SKI | – | 46, XX[20] | FLT3-ITD |
EFCAB2-ZNF238 | – | 46, XX [20] | FLT3-ITD |
BCR/ABL | BCR/ABL | NA | FLT3-TKD |
AML1/ETO | AML1/ETO | 45, X, -Y, t(8;21)(q22;q22)[22] | FLT3-TKD |
AML1/ETO | AML1/ETO | 46, XY,t(8;21)(q22;q22)[26]/46,XY[1] | FLT3-TKD |
AML1/ETO | AML1/ETO | 46, XX, t(8;21)(q22;q22)[20] | FLT3-TKD |
AML1/ETO | AML1/ETO | 45,X,?Xq-,?8q-,-22[1]/43,X,?Xq-,-8,-10,-22[1]/45,X,-X[1]/47,XX, + mar[1]/40,-X,-X,-11,-21,-22, + mar[1]/46,XX[4] | FLT3-TKD |
MLL/MLLT3 | – | 46, XX[20] | FLT3-TKD |
DEK/CAN | DEK/CAN | 47, XY, chtb(4)(?q31),? + 9,-15,inc[1]/46, XY[27]/hypodiploid [2] (44–45) | FLT3-TKD |
AML/MDS1 | – | 46, XY [20] | FLT3-TKD |
SLC45A3/ELK4 | – | 47, XY, + 8[7] | FLT3-TKD |
MLL/TMX2-CTNND1 | – | 42–47,XY, + 3,del(3)(p13),del(3)(q13),-4,?add(4)(q35),-8,-11,dic(11;?)(q25;?),-16,-17,-18,-19,-20, + r, + mar1, + mar2, + mar3,inc[cp22]/46,XY[1] | FLT3-TKD |
CBFB/MYH11 | CBFB/MYH11 | 47, XY, + 22[2]/46, XY[23] | FLT3-TKD |