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Table 2 Fusion genes by NGS and PCR and Chromosome karyotype analysis in FLT3 mutant AML

From: Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Fusion gene by NGS Fusion gene by PCR Chromosome karyotype FLT3 mutation
AML1/ETO AML1/ETO 46, XY, t(8;21)(q22;q22)[20] FLT3-ITD, FLT3-TKD
AML1/ETO AML1/ETO 46, X, -X,t(8;21)(q22;q22), del(9)(q22)[9]/46,XX,t(8;21)(q22;q22)[11] FLT3-ITD
AML1/ETO AML1/ETO 45, X, -X,t(8;21)[20] FLT3-ITD
MLL-PTD MLL-PTD 46, XY[20] FLT3-ITD
MLL-PTD MLL-PTD 46, XY[20] FLT3-ITD
MLL-PTD MLL-PTD 46, XX[20] FLT3-ITD
MLL-PTD MLL-PTD 47, XY, + 8?[10]/46, XY[10] FLT3-ITD
MLL/AF9 MLL/AF9 46, XX,?der(2)(q11),inc[1] /46,XX[28]/hypodiploid [4] (44–45) FLT3-ITD
MLL/AF9 MLL/AF9 47, XY, + 8[7] FLT3-ITD
MLL/ELL MLL/ELL 46, XX, t(11;19)(q23; q13)[10] FLT3-ITD
NUP98/HOXA9 NUP98/HOXA9 NA FLT3-ITD
NUP98/HOXA9 NUP98/HOXA9 46, XX[20] FLT3-ITD
NUP98/HOXA9 NUP98/HOXA9 NA FLT3-ITD
NUP98-NSD1 – 46, XX[20] FLT3-ITD
NUP98-NSD1 – 47, XX, + 6[14]/46, XX[6] FLT3-ITD
NUP98-NSD1 – 46, XY[20] FLT3-ITD
NUP98-NSD1 – 46, XY[25] FLT3-ITD
DEK/CAN DEK/CAN 46, XX[20] FLT3-ITD
DEK/CAN DEK/CAN 46, XY, ?t(6;9)(p23;34)[10]/46, XY,?t(6;9)(p23;q34),?del(8)(q21)[11]/46,XY[1] FLT3-ITD
PRDM16-SKI – 46, XX[20] FLT3-ITD
EFCAB2-ZNF238 – 46, XX [20] FLT3-ITD
BCR/ABL BCR/ABL NA FLT3-TKD
AML1/ETO AML1/ETO 45, X, -Y, t(8;21)(q22;q22)[22] FLT3-TKD
AML1/ETO AML1/ETO 46, XY,t(8;21)(q22;q22)[26]/46,XY[1] FLT3-TKD
AML1/ETO AML1/ETO 46, XX, t(8;21)(q22;q22)[20] FLT3-TKD
AML1/ETO AML1/ETO 45,X,?Xq-,?8q-,-22[1]/43,X,?Xq-,-8,-10,-22[1]/45,X,-X[1]/47,XX, + mar[1]/40,-X,-X,-11,-21,-22, + mar[1]/46,XX[4] FLT3-TKD
MLL/MLLT3 – 46, XX[20] FLT3-TKD
DEK/CAN DEK/CAN 47, XY, chtb(4)(?q31),? + 9,-15,inc[1]/46, XY[27]/hypodiploid [2] (44–45) FLT3-TKD
AML/MDS1 – 46, XY [20] FLT3-TKD
SLC45A3/ELK4 – 47, XY, + 8[7] FLT3-TKD
MLL/TMX2-CTNND1 – 42–47,XY, + 3,del(3)(p13),del(3)(q13),-4,?add(4)(q35),-8,-11,dic(11;?)(q25;?),-16,-17,-18,-19,-20, + r, + mar1, + mar2, + mar3,inc[cp22]/46,XY[1] FLT3-TKD
CBFB/MYH11 CBFB/MYH11 47, XY, + 22[2]/46, XY[23] FLT3-TKD
  1. NGS, next generation sequencing; PCR, polymerase chain reaction
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Experimental Hematology & Oncology

ISSN: 2162-3619

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