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Table 1 Clinical, cytogenetics and molecular genetics characteristic of 207 analyzed AML patients

From: Profiling of somatic mutations and fusion genes in acute myeloid leukemia patients with FLT3-ITD or FLT3-TKD mutation at diagnosis reveals distinct evolutionary patterns

Parameter FLT3-ITD
(n = 58)
FLT3-TKD
(n = 16)
FLT3wtAML
(n = 133)
P valuea
Male 23 (39.7) 12 (75) 80 (60.2) 0.009
Age 48 (14–73) 41 (14–76) 45 (15–76) 0.367
WBC at diagnosis, × 109/L 72.9 (2.3–405.1) 68.2 (1.8–251.1) 24.2 (0.57–311.0) 0.000
Blasts in BM, % 65.9 (22.0–95.6) 55.5 (30.8–94.0) 56.0 (14.4–94.5) 0.040
FAB subtype, n (%)     0.983
 M0 0 0 0  
 M1 3 (5.2) 1 (6.3) 4 (3.0)  
 M2 16 (27.6) 5 (31.3) 38 (28.6)  
 M4 20 (34.5) 6 (37.5) 41 (30.8)  
 M5 14 (24.1) 4 (25.0) 36 (27.1)  
 M6 2 (34) 0 5 (3.8)  
 Unclassified 1 (1.7) 0 6 (4.5)  
 Secondary-AML 2 (3.4) 0 3 (2.3)  
Cytogenetics, n (%) (n = 197)     
 Normal karyotypes 35 (64.8) 6 (40.0) 62 (48.4) 0.079
 Aberrant karyotypes 19 (35.2) 9 (60.9) 66 (51.6)  
Gene Mutationc, n (%)     
 NPM1 28 (53.8)& 4 (25) 20 (15.3) 0.000
 DNMT3A 18 (34.6)& 4 (25) 17(13.0) 0.003
 RUNX1 1 (1.7) 1 (6.3) 8 (6.1) 0.492
 KIT 3 (5.8) 0 (0) 6 (4.6) 0.623
 RAS 1 (1.9)& 1 (6.3) 27 (20.6) 0.003
 PTPN11 5 (9.6) 1 (6.3) 6 (6.3) 0.435
 TET2 6 (11.5) 1 (6.3) 10 (7.6) 0.656
 IDH1/2 5 (19.6) 3 (18.8) 20 (15.3) 0.522
 CEBPA 2 (3.8)& 0 (0) 26 (19.8) 0.005
 ASXL1 2 (3.8) 2 (12.5) 13 (9.9) 0.348
 TP53 0 (0)& 1/16 (6.3) 8 (6.1) 0.189
 Methylation-related genesb 23 (44.2) 6 (37.5) 42 (32.1) 0.297
 Number of mutations 3.2 (1–7)& 3.6 (1–6) 2.7 (0–8) 0.022
 CR after two cycles of induction 29/46 (63) 10/14 (71.4) 100/113 (88.5) 0.001
Consolidation in CR1     
 CT
 SCT
16 (55.2)
13 (44.8)
5 (50)
5 (50)
6 (49.5)
47 (50.5)
0.865
 Three-year OS (%) 36 ± 9.1 65.6 ± 15.1 50.6 ± 7 0.020
 Three-year EFS (%) 27.2 ± 8.1 55.9 ± 16.2 40.5 ± 6.5 0.005
  1. Italic values indicate significance of P value (P < 0.05)
  2. WBC white blood count, BM bone marrow, FAB French–America–British, CR complete remission, CT chemotherapy, SCT stem cell transplantation
  3. aP-values for categorical variables are from chi-square test, P-values for continuous variables are from the ANOVA test
  4. bMethylation related gene included DNMT3A, IDH1/2, and TET2
  5. c52 FLT3-ITD, 16 FLT3-TKD and 131 FLT3 wildtype patients were analyzed for gene mutations
  6. #p value for frequency of favorable, intermediate and unfavorable karyotype in three groups
  7. &P value < 0.05 between the FLT3-ITD group and FLT3wt group