Importance of monitoring arsenic methylation metabolism in acute promyelocytic leukemia patients receiving the treatment of arsenic trioxide

Table 3 SNPs of AS3MT and the urine arsenic methylation metabolism

SNPs^a	TAs (ng/mL)	iAs^III%	iAs^V%	MMA%	DMA%	PMI	SMI
9749
AA	43.66 ± 35.79	41.16 ± 31.22	10.55 ± 13.83	16.54 ± 13.44	23.39 ± 24.27	0.21 (0.02–2.39)	1.05 (0–41.17)
AG & GG	41.61 ± 30.20	29.04 ± 30.13	5.54 ± 6.39	5.96 ± 3.64	46.45 ± 33.32	0.21 (0.02–1.33)	7.5 (0–29.06)
P value	0.874	0.294	0.296	0.024	0.02	0.989	0.011
27215
AA	41.66 ± 30.47	43.23 ± 30.00	9.09 ± 12.62	15.69 ± 13.04	23.11 ± 23.08	0.20 (0.02–2.39)	0.96 (0–143.01)
AG & GG	54.73 ± 39.34	23.73 ± 27.78	6.29 ± 6.38	9.42 ± 14.73	41.65 ± 34.93	0.26 (0.02–1.53)	6.41 (0–41.17)
P value	0.209	0.044	0.458	0.147	0.027	0.71	0.017

SNP: single nucleotide polymorphism; AS3MT: (+ 3 oxidative state) methylation transferase; TAs: total arsenic; iAs^III%: inorganic arsenite/TAs × 100%; iAs^V%: inorganic arsenate/TAs × 100%; MMA%: monomethylarsonic acid/TAs × 100%; DMA%: dimethylarsinic acid/TAs × 100%. PMI: primary methylation index; SMI: secondary methylation index
^aAll the other SNPs of AS3MT showed no significant influence on arsenic metabolism, therefore only A9749G and A27215G are presented

ISSN: 2162-3619