Table 2 FMT and Microbiota related clinical trials
From: Applications of gut microbiota in patients with hematopoietic stem-cell transplantation
Clinical TRIALS. gov identifier | Clinical trial title | Phase | Enrollment number | Disease conditions | Status | Lead institution/location |
|---|---|---|---|---|---|---|
NCT02641236 | Gut Decontamination in Pediatric Allogeneic Hematopoietic | 2 | 28 | HSCT, aGvHD | Recruiting | Boston Children's Hospital Boston, Massachusetts, United States |
NCT03148197 | Changes in the Gut Microbiota of Patients Undergoing Allogeneic Stem Cell Transplantation (COLLECT) | 1, 2 | 30 | AML, GvHD, Allogeneic HSCT, HSCT complications | Unknown | University Hospital of Cologne Cologne, Germany |
NCT03214289 | Fecal Microbiota Transplantation for Steroid Resistant and Steroid Dependent Gut Acute Graft Versus Host Disease | 1 | 4 | HSCT complications GvHD, Acute FMT | Unknown | Chaim Sheba Medical Center Ramat Gan, Israel |
NCT03616015 | Dysbiosis and Immune Reconstitution After Allo-HSCT | Not applicable | 80 | HSCT | Recruiting | RUBIO Marie-Thérèse Vandoeuvre Les Nancy, France |
NCT03678493 | A Study of FMT in Patients With AML Allo HSCT in Recipients | 2 | 120 | AML, Allogeneic HSCT | Recruiting | Masonic Cancer Center at University of Minnesota Minneapolis, Minnesota, United States |
NCT03720392 | Fecal Microbiota Transplantation (FMT) in Recipients After Allogeneic Hematopoietic Cell Transplantation (HCT) | 2 | 48 | Allogeneic HSCT | Active, not recruiting | Massachusetts General Hospital Cancer Center Boston, Massachusetts, United States |
NCT03812705 | Fecal Microbiota Transplantation for Steroid Resistant/Dependent Acute GI GVHD | 2 | 30 | Hematopoietic and lymphoid cell neoplasm | Recruiting | Shanghai Jiao Tong University Affilated First People's Hospital, Shanghai, Shanghai, China |
NCT03819803 | Fecal Microbiota Transplantation in aGvHD After ASCT | 3 | 15 | GvHD in GI Tract | Recruiting | Division of Gastroenterology and Hepatology, Department of Internal Medicine, Medical University of Graz Graz, Styria, Austria |
NCT04111471 | The Use of A Prebiotic to Promote a Healthy Gut Microbiome in Pediatric Stem Cell Transplant Recipients | Not applicable | 40 | Microbial colonization | Recruiting | Ann & Robert H Lurie Children's Hospital of Chicago Chicago, Illinois, United States |
NCT04139577 | FMT In High-Risk Acute GVHD After ALLO HCT | 1 | 11 | aGvHD, HSCT, FMT | Not yet recruiting | Dana Farber Cancer Institute Boston, Massachusetts, United States |
NCT04203017 | Fecal Microbiota Transplantation After Autologous HSCT in Patients With Multiple Sclerosis | 1 | 20 | Multiple Sclerosis | Recruiting | Pavlov First Saint-Petersburg State Medical University Saint Petersburg, Russian Federation |
NCT04269850 | Fecal Microbiota Transplantation With Ruxolitinib and Steroids as an Upfront Treatment of Severe Acute Intestinal GVHD | 1, 2 | 20 | Intestinal GVHD | Recruiting | Pavlov First Saint-Petersburg State Medical University Saint Petersburg, Russian Federation |
NCT04281797 | Intestinal Microbiome Dynamics in Solid Organ and Stem Cell Transplant Recipients | Not applicable | 90 | Transplantation infection Kidney transplant; Complications HSCT complications | Enrolling by invitation | Minsk Scientific-Practical Center for Surgery, Transplantation and Hematology Minsk, Belarus |
NCT04285424 | FMT for Steroid Resistant Gut Acute GVHD | 1 | 30 | HSCT complications aGvHD, FMT | Recruiting | Affiliated Hospital to Academy of Military Medical Sciences, Beijing, Beijing, China |