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Table 3 The DALYs and age-standardized DALYs Rate of CML in 1990 and 2017, and its temporal trends from 1990 to 2017

From: Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study

  DALYs No. *103 (95% UI) Change in absolute number (%) Age-standardized DALY rate per 100,000 no. (95% UI) 1990–2017 EAPCs No. (95% CI)
1990 2017 1990 2017
Overall 734.92 (666.26–806.31) 654.98 (594.73–712.95) − 10.88 15.96 (14.6–17.44) 8.17 (7.42–8.88) − 2.84 (− 2.98 to − 2.69)
Sex
 Male 382.94 (349.15–415.35) 347.24 (308.67–383.12) − 9.32 17.48 (16.08–18.92) 9 (8.01–9.9) − 2.79 (− 2.93 to − 2.65)
 Female 351.99 (299.2–414.08) 307.74 (258.51–357.55) − 12.57 14.78 (12.72–17.36) 7.48 (6.27–8.68) − 2.89 (− 3.04 to − 2.75)
Socio-demographic index
 High SDI 286.21 (278.31–294.78) 125.91 (121.16–131.32) − 56.01 24.23 (23.53–24.96) 6.81 (6.57–7.08) − 5.34 (− 5.6 to − 5.08)
 High-middle SDI 129.2 (112.36–144.95) 91.51 (85–100.26) − 29.17 12.17 (10.67–13.57) 5.26 (4.9–5.76) − 3.58 (− 3.84 to − 3.32)
 Middle SDI 110.8 (96.98–129.21) 137.8 (120.1–148.24) 24.37 8.68 (7.68–10.09) 6.03 (5.25–6.47) − 1.6 (− 1.73 to − 1.48)
 Low-middle SDI 100.72 (86–128.82) 146.73 (127.78–171.91) 45.68 13.25 (11.49–16.8) 10.33 (8.95–12.07) − 1 (− 1.14 to − 0.87)
 Low SDI 106.41 (82.75–137.73) 151.91 (126.85–172.16) 42.76 23.14 (18.45–29.19) 16.71 (14.03–18.84) − 1.35 (− 1.42 to − 1.28)
Region
 Andean Latin America 2.58 (2.16–2.98) 4.49 (3.61–5.14) 73.96 9.01 (7.53–10.28) 7.68 (6.21–8.76) − 0.45 (− 0.59 to − 0.32)
 Australasia 6.8 (6.49–7.13) 4.02 (3.54–4.58) − 40.85 29.19 (27.86–30.62) 9.87 (8.64–11.2) − 4.84 (− 5.13 to − 4.54)
 Caribbean 6.72 (6.12–7.52) 6.66 (5.9–7.62) − 0.77 22.56 (20.54–25.15) 13.28 (11.77–15.18) − 2.11 (− 2.28 to − 1.93)
 Central Asia 7.39 (6.31–8.47) 6.69 (5.93–7.44) − 9.46 12.76 (10.93–14.6) 7.62 (6.77–8.45) − 2.08 (− 2.32 to − 1.84)
 Central Europe 27.55 (26.09–29.01) 13.52 (12.8–14.32) − 50.92 19.12 (18.14–20.16) 7.53 (7.14–7.98) − 3.76 (− 3.97 to − 3.55)
 Central Latin America 19.46 (18.71–20.35) 24.79 (23.35–26.32) 27.39 16.88 (16.22–17.64) 9.98 (9.41–10.58) − 2.34 (− 2.55 to − 2.13)
 Central Sub-Saharan Africa 4.86 (3.14–6.32) 11.01 (7.99–13.7) 126.38 14.47 (9.83–18.41) 14.97 (10.91–18.55) 0.26 (0.16 to 0.36)
 East Asia 62.56 (46.66–79.09) 36.19 (30.76–43.35) − 42.15 5.02 (3.85–6.27) 1.9 (1.63–2.27) − 4.37 (− 4.73 to − 4.02)
 Eastern Europe 44.34 (40.1–50.69) 32.48 (30.66–34.41) − 26.74 16.35 (14.87–18.62) 10.85 (10.26–11.55) − 2.04 (− 2.47 to − 1.61)
 Eastern Sub-Saharan Africa 37.33 (26.7–51.97) 51.15 (39.01–62.33) 37.04 32.79 (24.4–43.98) 21.72 (16.64–26.33) − 1.82 (− 1.95 to − 1.69)
 High-income Asia Pacific 34.19 (32.85–35.83) 11.61 (10.84–12.33) − 66.04 17.16 (16.47–18.02) 3.85 (3.59–4.12) − 5.94 (− 6.17 to − 5.72)
 High-income North America 73.89 (71.98–76.1) 31.36 (29.89–33.21) − 57.56 22.53 (21.93–23.2) 6.14 (5.82–6.5) − 5.78 (− 6.24 to − 5.33)
 North Africa and Middle East 33.74 (24.28–41.55) 39.69 (32.3–47.11) 17.63 14.58 (10.63–17.84) 7.66 (6.27–9) − 2.49 (− 2.56 to − 2.41)
 Oceania 1.06 (0.79–1.44) 1.65 (1.2–2.34) 55.08 23.03 (17.52–30.17) 16.36 (12.26–22.41) − 1.29 (− 1.36 to − 1.23)
 South Asia 140.17 (116.31–172.87) 207.79 (180.43–239.39) 48.24 17.35 (14.7–21.55) 13.25 (11.44–15.19) − 1.08 (− 1.19 to − 0.96)
 Southeast Asia 36.28 (28.98–52.09) 52.2 (41.39–62.2) 43.89 10.3 (8.45–15) 7.87 (6.24–9.39) − 1.02 (− 1.16 to − 0.87)
 Southern Latin America 9.22 (8.5–9.93) 5.36 (4.81–5.91) − 41.85 19.28 (17.79–20.78) 7 (6.27–7.73) − 4.32 (− 4.73 to − 3.91)
 Southern Sub-Saharan Africa 0.98 (0.73–1.19) 1.26 (0.93–1.57) 29.18 2.63 (1.96–3.24) 1.88 (1.39–2.3) − 1.15 (− 1.8 to − 0.49)
 Tropical Latin America 20.5 (19.63–21.45) 15.79 (15.04–16.59) − 22.97 16.99 (16.31–17.74) 6.64 (6.33–6.97) − 3.92 (− 4.32 to − 3.52)
 Western Europe 150.45 (144.73–156.46) 68.46 (64.8–72.73) − 54.49 28.93 (27.85–30.07) 8.84 (8.39–9.38) − 4.97 (− 5.25 to − 4.69)
 Western Sub-Saharan Africa 14.87 (11.7–18.64) 28.79 (23.26–37.07) 93.7 12.23 (9.58–15.37) 10.82 (8.63–13.73) − 0.51 (− 0.55 to − 0.47)
  1. DALYs disability-adjusted life years, CI confidence interval, EAPCs estimated annual percentage changes, UI uncertainty interval