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Table 3 The DALYs and age-standardized DALYs Rate of CML in 1990 and 2017, and its temporal trends from 1990 to 2017

From: Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study

 

DALYs No. *103 (95% UI)

Change in absolute number (%)

Age-standardized DALY rate per 100,000 no. (95% UI)

1990–2017 EAPCs No. (95% CI)

1990

2017

1990

2017

Overall

734.92 (666.26–806.31)

654.98 (594.73–712.95)

− 10.88

15.96 (14.6–17.44)

8.17 (7.42–8.88)

− 2.84 (− 2.98 to − 2.69)

Sex

 Male

382.94 (349.15–415.35)

347.24 (308.67–383.12)

− 9.32

17.48 (16.08–18.92)

9 (8.01–9.9)

− 2.79 (− 2.93 to − 2.65)

 Female

351.99 (299.2–414.08)

307.74 (258.51–357.55)

− 12.57

14.78 (12.72–17.36)

7.48 (6.27–8.68)

− 2.89 (− 3.04 to − 2.75)

Socio-demographic index

 High SDI

286.21 (278.31–294.78)

125.91 (121.16–131.32)

− 56.01

24.23 (23.53–24.96)

6.81 (6.57–7.08)

− 5.34 (− 5.6 to − 5.08)

 High-middle SDI

129.2 (112.36–144.95)

91.51 (85–100.26)

− 29.17

12.17 (10.67–13.57)

5.26 (4.9–5.76)

− 3.58 (− 3.84 to − 3.32)

 Middle SDI

110.8 (96.98–129.21)

137.8 (120.1–148.24)

24.37

8.68 (7.68–10.09)

6.03 (5.25–6.47)

− 1.6 (− 1.73 to − 1.48)

 Low-middle SDI

100.72 (86–128.82)

146.73 (127.78–171.91)

45.68

13.25 (11.49–16.8)

10.33 (8.95–12.07)

− 1 (− 1.14 to − 0.87)

 Low SDI

106.41 (82.75–137.73)

151.91 (126.85–172.16)

42.76

23.14 (18.45–29.19)

16.71 (14.03–18.84)

− 1.35 (− 1.42 to − 1.28)

Region

 Andean Latin America

2.58 (2.16–2.98)

4.49 (3.61–5.14)

73.96

9.01 (7.53–10.28)

7.68 (6.21–8.76)

− 0.45 (− 0.59 to − 0.32)

 Australasia

6.8 (6.49–7.13)

4.02 (3.54–4.58)

− 40.85

29.19 (27.86–30.62)

9.87 (8.64–11.2)

− 4.84 (− 5.13 to − 4.54)

 Caribbean

6.72 (6.12–7.52)

6.66 (5.9–7.62)

− 0.77

22.56 (20.54–25.15)

13.28 (11.77–15.18)

− 2.11 (− 2.28 to − 1.93)

 Central Asia

7.39 (6.31–8.47)

6.69 (5.93–7.44)

− 9.46

12.76 (10.93–14.6)

7.62 (6.77–8.45)

− 2.08 (− 2.32 to − 1.84)

 Central Europe

27.55 (26.09–29.01)

13.52 (12.8–14.32)

− 50.92

19.12 (18.14–20.16)

7.53 (7.14–7.98)

− 3.76 (− 3.97 to − 3.55)

 Central Latin America

19.46 (18.71–20.35)

24.79 (23.35–26.32)

27.39

16.88 (16.22–17.64)

9.98 (9.41–10.58)

− 2.34 (− 2.55 to − 2.13)

 Central Sub-Saharan Africa

4.86 (3.14–6.32)

11.01 (7.99–13.7)

126.38

14.47 (9.83–18.41)

14.97 (10.91–18.55)

0.26 (0.16 to 0.36)

 East Asia

62.56 (46.66–79.09)

36.19 (30.76–43.35)

− 42.15

5.02 (3.85–6.27)

1.9 (1.63–2.27)

− 4.37 (− 4.73 to − 4.02)

 Eastern Europe

44.34 (40.1–50.69)

32.48 (30.66–34.41)

− 26.74

16.35 (14.87–18.62)

10.85 (10.26–11.55)

− 2.04 (− 2.47 to − 1.61)

 Eastern Sub-Saharan Africa

37.33 (26.7–51.97)

51.15 (39.01–62.33)

37.04

32.79 (24.4–43.98)

21.72 (16.64–26.33)

− 1.82 (− 1.95 to − 1.69)

 High-income Asia Pacific

34.19 (32.85–35.83)

11.61 (10.84–12.33)

− 66.04

17.16 (16.47–18.02)

3.85 (3.59–4.12)

− 5.94 (− 6.17 to − 5.72)

 High-income North America

73.89 (71.98–76.1)

31.36 (29.89–33.21)

− 57.56

22.53 (21.93–23.2)

6.14 (5.82–6.5)

− 5.78 (− 6.24 to − 5.33)

 North Africa and Middle East

33.74 (24.28–41.55)

39.69 (32.3–47.11)

17.63

14.58 (10.63–17.84)

7.66 (6.27–9)

− 2.49 (− 2.56 to − 2.41)

 Oceania

1.06 (0.79–1.44)

1.65 (1.2–2.34)

55.08

23.03 (17.52–30.17)

16.36 (12.26–22.41)

− 1.29 (− 1.36 to − 1.23)

 South Asia

140.17 (116.31–172.87)

207.79 (180.43–239.39)

48.24

17.35 (14.7–21.55)

13.25 (11.44–15.19)

− 1.08 (− 1.19 to − 0.96)

 Southeast Asia

36.28 (28.98–52.09)

52.2 (41.39–62.2)

43.89

10.3 (8.45–15)

7.87 (6.24–9.39)

− 1.02 (− 1.16 to − 0.87)

 Southern Latin America

9.22 (8.5–9.93)

5.36 (4.81–5.91)

− 41.85

19.28 (17.79–20.78)

7 (6.27–7.73)

− 4.32 (− 4.73 to − 3.91)

 Southern Sub-Saharan Africa

0.98 (0.73–1.19)

1.26 (0.93–1.57)

29.18

2.63 (1.96–3.24)

1.88 (1.39–2.3)

− 1.15 (− 1.8 to − 0.49)

 Tropical Latin America

20.5 (19.63–21.45)

15.79 (15.04–16.59)

− 22.97

16.99 (16.31–17.74)

6.64 (6.33–6.97)

− 3.92 (− 4.32 to − 3.52)

 Western Europe

150.45 (144.73–156.46)

68.46 (64.8–72.73)

− 54.49

28.93 (27.85–30.07)

8.84 (8.39–9.38)

− 4.97 (− 5.25 to − 4.69)

 Western Sub-Saharan Africa

14.87 (11.7–18.64)

28.79 (23.26–37.07)

93.7

12.23 (9.58–15.37)

10.82 (8.63–13.73)

− 0.51 (− 0.55 to − 0.47)

  1. DALYs disability-adjusted life years, CI confidence interval, EAPCs estimated annual percentage changes, UI uncertainty interval