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Table 1 The incidence cases and ASIR of CML in 1990 and 2017, and its temporal trends from 1990 to 2017

From: Trends in disease burden of chronic myeloid leukemia at the global, regional, and national levels: a population-based epidemiologic study

  Incident cases no. *102 (95% UI) Change in absolute number (%) ASIR per 100,000 No. (95% UI) 1990–2017 EAPCs No. (95% CI)
1990 2017 1990 2017
Overall 317.52 (295.9–340.66) 341.79 (315.16–367.14) 7.64 0.75 (0.71–0.8) 0.43 (0.4–0.46) -2.4 (− 2.53 to − 2.26)
Sex
 Male 165.57 (153.46–177.23) 191.45 (173.2–208.22) 15.64 0.86 (0.8–0.92) 0.52 (0.47–0.57) − 2.17 (− 2.29 to − 2.05)
 Female 151.96 (135.82–171.91) 150.33 (130.96–170.43) − 1.07 0.67 (0.61–0.75) 0.36 (0.31–0.41) − 2.7 (− 2.85 to − 2.55)
Socio- demographic index
 High SDI 163.42 (157.15–169.51) 106.4 (100.95–112.18) − 34.89 1.34 (1.29–1.38) 0.53 (0.51–0.56) − 4 (− 4.23 to − 3.78)
 High-middle SDI 49.58 (43.76–55.26) 57.35 (52.42–62.39) 15.69 0.49 (0.43–0.54) 0.33 (0.3–0.36) − 1.77 (− 1.95 to − 1.6)
 Middle SDI 38.31 (34.17–44.49) 67.71 (58.04–72.69) 76.73 0.33 (0.3–0.39) 0.3 (0.26–0.32) − 0.56 (− 0.66 to − 0.45)
 Low-middle SDI 32.8 (28.42–41.59) 56.67 (49.19–65.98) 72.79 0.48 (0.42–0.61) 0.43 (0.37–0.5) − 0.48 (− 0.6 to − 0.36)
 Low SDI 32.8 (25.9–41.69) 52.85 (44.44–59.95) 61.14 0.81 (0.67–1.01) 0.65 (0.55–0.74) − 0.93 (− 0.97 to − 0.88)
Region
 Andean Latin America 0.87 (0.73–1) 2.08 (1.69–2.39) 138.66 0.34 (0.28–0.38) 0.36 (0.29–0.42) 0.46 (0.32–0.6)
 Australasia 3.87 (3.36–4.44) 3.58 (2.95–4.32) − 7.43 1.64 (1.43–1.87) 0.83 (0.68–1) − 3.35 (− 3.66 to − 3.03)
 Caribbean 2.64 (2.41–2.91) 3.07 (2.73–3.48) 16.28 0.93 (0.85–1.02) 0.61 (0.54–0.69) − 1.7 (− 1.84 to − 1.57)
 Central Asia 2.52 (2.16–2.88) 2.74 (2.41–3.07) 8.73 0.45 (0.39–0.51) 0.32 (0.28–0.36) − 1.34 (− 1.57 to − 1.11)
 Central Europe 11.11 (10.48–11.77) 6.82 (6.42–7.27) − 38.62 0.77 (0.73–0.82) 0.37 (0.35–0.4) − 2.87 (− 3.14 to − 2.6)
 Central Latin America 6.98 (6.69–7.4) 11.96 (11.22–12.85) 71.35 0.66 (0.64–0.7) 0.49 (0.46–0.53) − 1.47 (− 1.7 to − 1.23)
 Central Sub-Saharan Africa 1.49 (0.99–1.92) 3.61 (2.64–4.51) 142.15 0.51 (0.35–0.64) 0.57 (0.42–0.72) 0.58 (0.47 to 0.69)
 East Asia 22.64 (17.43–28.02) 32.71 (27.97–37.64) 44.49 0.19 (0.16–0.24) 0.17 (0.15–0.19) − 0.99 (− 1.21 to − 0.76)
 Eastern Europe 18.01 (15.98–20.72) 18.51 (16.46–20.67) 2.77 0.66 (0.59–0.75) 0.61 (0.54–0.69) − 0.55 (− 0.86 to − 0.25)
 Eastern Sub-Saharan Africa 11.1 (8.15–15.09) 16.39 (12.56–19.89) 47.6 1.11 (0.86–1.49) 0.81 (0.63–0.98) − 1.41 (− 1.51 to − 1.31)
 High-income Asia Pacific 17.08 (15.68–18.57) 12.81 (11.33–14.46) − 25.03 0.87 (0.79–0.94) 0.39 (0.34–0.44) − 3.2 (− 3.37 to − 3.02)
High-income North America 34.1 (32.98–35.37) 20.55 (19.44–21.81) − 39.75 1.02 (0.98–1.06) 0.4 (0.37–0.43) − 4.28 (− 4.66 to − 3.9)
 North Africa and Middle East 11.85 (8.69–14.29) 18.32 (15.18–21.5) 54.62 0.57 (0.42–0.69) 0.38 (0.32–0.44) − 1.59 (− 1.67 to − 1.52)
 Oceania 0.33 (0.25–0.44) 0.55 (0.41–0.78) 67.15 0.78 (0.6–1) 0.59 (0.45–0.79) − 1.06 (− 1.09 to − 1.03)
 South Asia 44.97 (38.05–55.49) 80.44 (69.27–91.61) 78.87 0.64 (0.55–0.79) 0.56 (0.48–0.63) − 0.58 (− 0.68 to − 0.48)
 Southeast Asia 12.41 (10.18–17.69) 25.17 (19.85–29.4) 102.88 0.39 (0.33–0.57) 0.4 (0.31–0.46) 0.05 (− 0.08 to 0.17)
 Southern Latin America 3.77 (3.47–4.09) 3 (2.69–3.35) − 20.44 0.8 (0.73–0.87) 0.38 (0.34–0.43) − 3.29 (− 3.71 to − 2.88)
 Southern Sub-Saharan Africa 0.33 (0.25–0.42) 0.48 (0.36–0.6) 46.63 0.1 (0.07–0.12) 0.08 (0.06–0.09) − 0.77 (− 1.37 to − 0.16)
 Tropical Latin America 7.2 (6.88–7.55) 7.65 (7.26–8.15) 6.36 0.65 (0.62–0.68) 0.33 (0.31–0.35) − 2.93 (− 3.34 to − 2.53)
 Western Europe 99.5 (94.04–104.66) 61.62 (56.85–66.77) − 38.07 1.78 (1.69–1.87) 0.69 (0.64–0.75) − 4.12 (− 4.34 to − 3.89)
 Western Sub-Saharan Africa 4.74 (3.75–5.92) 9.72 (7.87–12.33) 105.04 0.43 (0.34–0.54) 0.42 (0.33–0.52) − 0.13 (− 0.16 to − 0.11)
  1. ASIR age-standardized incidence rate, CI confidence interval, EAPCs estimated annual percentage changes, UI uncertainty interval