Table 2 Clinical practices compared between PDAC, PanNEC and PanNET
| Â | PDAC | PanNEC | PanNET |
|---|---|---|---|
Diagnosis | |||
 Serum test | CA199, CEA,CA125 | NSE CA199, CEA, AFP | CgA, 5-HIAA Functional hormone |
 Imaging | Computer tomography Magnetic resonance imaging F18-FDG PET/CT | Computer tomography Magnetic resonance imaging F18-FDG PET/CT | Computer tomography Magnetic resonance imaging Ga68-DOTATATE PET/CT Somatostatin receptor scintigraphy |
Therapy | |||
 Localized | Resection Neoadjuvent chemo + resection | Resection | Active surveillance Resection |
 Advanced and metastasis | SYSTEM TREATMENT Irinotecan + Oxaliplatin + fluorouracil Gemcitabine + Albumin-Paclitaxel Clinical trials OTHERS Radiotherapy | SYSTEM TREATMENT Etoposide + cisplatin Irinotecan + cisplatin Clinical trials OTHERS Radiotherapy | LOCAL TREATMENT Debulking surgery Transarterial chemoembolization, Ablation of liver metastasis SYSTEM TREATMENT Somatostatin analogs Sunitinib and everolimus Temozolomidecapecitabine |
Follow-up | 3Â months | 3Â months | Localized 6-12Â months; Metastasis 3-6Â months |