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Table 1 Summary of the core pathways and genes in PDAC, PanNET and PanNEC

From: Molecular drivers and cells of origin in pancreatic ductal adenocarcinoma and pancreatic neuroendocrine carcinoma

Pathways PDAC PanNET PanNEC
RAS/MAPK signaling KRAS, MAP2K4   KRAS, BRAF
NF-kB signaling NF-κB, IKK   
JAK/STAT signaling MAP4K3, TNF, BCL2   BCL2
TGFb/SMAD signaling TGF-bR2, SMAD4   
Wnt/b-catenin signaling DKK1, HMGA2   WNT
Hedgehog signaling SOX3,GLI1,GLI3, TBX5, LRP2   LRP2
Hippo signaling YAP, TAZ   
SWI/SNF ARID1A   
Small GTPase-dependent signaling DEPDC2   
Notch signaling MYC, GATA6 NOTCH1, HES1  
DNA damage repair TP53, BRCA1, BRCA2 TP53, MDM2, MDM4 TP53
Cell cycle CDKN2A, APC2, FBXW7, CHD1 CDK4, p16,p27 RB1, APC, CDKN2A, FBXW7
c-MET   MET  
PI3K/AKt signaling   PTEN, PI3KCA, AKT, mTOR, TSC1/2 PTEN, PI3KCA, mTOR
Chromatin remodeling   DAXX,ATRX, MDM2  
Angiogenesis pathway HIF-1, BNIP3 HIF-1a, VEGF, PDGF, PHDs,Kit, Tie-2  
Menin pathway   MEN1, MLL