|
RAS/MAPK signaling
|
KRAS, MAP2K4
| |
KRAS, BRAF
|
|
NF-kB signaling
|
NF-κB, IKK
| | |
|
JAK/STAT signaling
|
MAP4K3, TNF, BCL2
| |
BCL2
|
|
TGFb/SMAD signaling
|
TGF-bR2, SMAD4
| | |
|
Wnt/b-catenin signaling
|
DKK1, HMGA2
| |
WNT
|
|
Hedgehog signaling
|
SOX3,GLI1,GLI3, TBX5, LRP2
| |
LRP2
|
|
Hippo signaling
|
YAP, TAZ
| | |
|
SWI/SNF
|
ARID1A
| | |
|
Small GTPase-dependent signaling
|
DEPDC2
| | |
|
Notch signaling
|
MYC, GATA6
|
NOTCH1, HES1
| |
|
DNA damage repair
|
TP53, BRCA1, BRCA2
|
TP53, MDM2, MDM4
|
TP53
|
|
Cell cycle
|
CDKN2A, APC2, FBXW7, CHD1
|
CDK4, p16,p27
|
RB1, APC, CDKN2A, FBXW7
|
|
c-MET
| |
MET
| |
|
PI3K/AKt signaling
| |
PTEN, PI3KCA, AKT, mTOR, TSC1/2
|
PTEN, PI3KCA, mTOR
|
|
Chromatin remodeling
| |
DAXX,ATRX, MDM2
| |
|
Angiogenesis pathway
|
HIF-1, BNIP3
|
HIF-1a, VEGF, PDGF, PHDs,Kit, Tie-2
| |
|
Menin pathway
| |
MEN1, MLL
| |
