Fig. 1
From: Regulation of metabolic reprogramming by tumor suppressor genes in pancreatic cancer
The mechanisms of glucose metabolism alteration regulated by p53 in pancreatic cancer. The positive regulations are shown in arrows, and the negative regulations are shown in T-bar lines. TIGAR, TP53-induced glycolysis and apoptosis regulator; RRAD, Ras-related associated with diabetes; SCO2, synthesis of cytochrome oxidase 2; COX, cytochrome c oxidase; Fru-2,6-P2: fructose-2,6-bisphosphate; GLUT, glucose transporter; MCT: monocarboxylate transporter; MPC: mitochondrial pyruvate carrier