Fig. 4

Relationships among CD8⁺ T cell infiltration, PD-1⁺ Tils infiltration, PD-L1, and TMB. a Representative images of PD-1⁺ Tils, CD8⁺ T cells, and CD8⁺PD-1⁺ T cells in the same slide from a lung adenocarcinoma sample evaluated by multiplex immunohistochemical staining. 20× magnification. b Correlation analysis between PD-1⁺ Tils and CD8⁺ T cells. Spearman correlation test. c, d The median proportion of CD8⁺PD-1⁺ T cells in total PD-1⁺ Tils and total CD8⁺ T cells. In the brackets is the interquartile range (IQR). e Correlation analysis between PD-L1 and CD8⁺ T cells. Spearman correlation test. f Correlation analysis between TMB and CD8⁺ T cells. Spearman correlation test