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Table 2 Laboratory examination at admission

From: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients

  All patients (N = 178) Nonsevere (N = 129) Severe (N = 49) P value
Blood cell counts     
 White blood cells (3.5–9.5*109/L) 5.95 (4.50–8.09) 5.40 (4.40–7.05) 7.90 (5.65–10.05) 0.000
 Neutrophils (1.8–6.3*109/L) 3.90 (2.66–5.64) 3.51 (2.45–4.85) 6.20 (3.88–8.51) 0.000
 Lymphocytes (1.1–3.2*109/L) 1.20 (0.82–1.61) 1.29 (0.98–1.69) 0.73 (0.45–1.22) 0.000
 Monocytes (0.1–0.6*109/L) 0.42 (0.30–0.60) 0.42 (0.32–0.62) 0.38 (0.27–0.55) 0.547
 Eosinophils (0.02–0.52*109/L) 0.08 (0.03–0.14) 0.09 (0.05–0.14) 0.03 (0.01–0.10) 0.343
 Basophils (0–0.06*109/L) 0.02 (0.01–0.03) 0.02 (0.01–0.03) 0.01 (0.00–0.02) 0.004
 Hemoglobin (130–175 g/L) 126.00 (115.00–133.25) 126.00 (117.50–134.00) 127.00 (111.50–132.50) 0.114
 Platelets (125–350*109/L) 236.00 (169.50–305.25) 251.00 (202.00–317.00) 186.00 (103.50– 249.00) 0.000
Coagulation function     
 PT (9.2–15 s) 13.17 (12.30–14.22) 12.70 (12.15–13.59) 14.55 (13.40–16.53) 0.000
 INR (0.8–1.25) 1.1 (1.03–1.19) 1.06 (1.01–1.13) 1.21 (1.13–1.36) 0.000
 PT % (70–125) 94.3% (89.53%–98.48%) 96.4% (92.1%–99.3%) 87.60% (80.10%–92.15%) 0.000
 APTT (21–37 s) 27.54 (25.31–30.18) 25.99 (25.11–29.33) 29.25 (26.95–32.84) 0.057
 FIB (2–4 g/L) 3.26 (2.79–3.99) 3.23 (2.80–3.70) 3.62 (2.70–4.33) 0.780
 TT (10–20 s) 15.91 (14.94–15.83) 15.68 (14.79–16.69) 16.35 (15.69–17.47) 0.011
 D-Dimer (0–0.55 mg/L) 0.56 (0.33–1.12) 0.42 (0.28–0.79) 1.05 (0.68–5.90) 0.000
Blood biochemistry     
 ALT (9–50 IU/L) 29.85 (16.60–52.63) 28.80 (15.75–50.15) 30.80 (19.00–58.30) 0.487
 AST (9–60 IU/L) 23.90 (17.20–36.60) 22.6 (16.7–32.03) 27.80 (19.30–40.55) 0.102
 TP (68–85 g/L) 62.60 (57.50–67.30) 63.95 (67.95– 58.85) 57.80 (52.80–63.15) 0.000
 ALB (40–50 g/L) 34.50 (30.30–38.00) 36.00 (32.88–39.10) 30.90 (27.60–33.65) 0.000
 GLB (20–35 g/L) 34.50 (30.30–38.00) 26.70 (25.20–29.60) 26.50 (23.90–31.40) 0.576
 Blood glucose (3.9–6.11 mmol/L) 5.22 (4.64–6.55) 5.06 (4.61–5.84) 6.15 (5.08–9.16) 0.002
 B–type natriuretic peptide (0–100 pg/mL) 11.05 (0.01–48.24) 0.01 (0.01–33.74) 40.55 (2.52–116.64) 0.052
 Serum creatinine (57–97 μmol/L) 66.70 (56.83–78.85) 67.35 (57.88–77.75) 65.35 (55.78–79.45) 0.402
 LDH(120–250 IU/L) 196.10 (164.80–278.70) 188.25 (162.13–219.33) 302.70 (198.90–479.00) 0.000
 Myoglobin (0–65 ng/mL) 7.58 (3.36–21.46) 5.13 (2.92–11.97) 25.14 (9.05–30.22) 0.022
 Troponin (0–0.04 ng/mL) 0.01 (0.01–0.01) 0.01 (0.01–0.01) 0.01 (0.01–0.05) 0.125
Infection related parameters     
 PCT (0–0.05 ng/mL) 0.05 (0.03–0.12) 0.03 (0.03–0.07) 0.13 (0.07–0.21) 0.564
 CRP (0–4 mg/L) 7.25 (1.59–60.74) 4.22 (0.96–15.75) 64.74 (6.58–119.03) 0.000
  1. Data are median value (interquartile range)
  2. PT prothrombin time, INR international normalized ratio, APTT activated partial thromboplastin time, FIB fibrinogen, TT thrombin time, LDH lactate dehydrogenase, ALT alanine aminotransferase, AST aspartate aminotransferase, TP total protein, ALB albumin, GLB globulin, PCT procalcitonin, CRP C-reactive protein