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Table 2 Laboratory examination at admission

From: SARS-CoV-2 induced thrombocytopenia as an important biomarker significantly correlated with abnormal coagulation function, increased intravascular blood clot risk and mortality in COVID-19 patients

 

All patients (N = 178)

Nonsevere (N = 129)

Severe (N = 49)

P value

Blood cell counts

    

 White blood cells (3.5–9.5*109/L)

5.95 (4.50–8.09)

5.40 (4.40–7.05)

7.90 (5.65–10.05)

0.000

 Neutrophils (1.8–6.3*109/L)

3.90 (2.66–5.64)

3.51 (2.45–4.85)

6.20 (3.88–8.51)

0.000

 Lymphocytes (1.1–3.2*109/L)

1.20 (0.82–1.61)

1.29 (0.98–1.69)

0.73 (0.45–1.22)

0.000

 Monocytes (0.1–0.6*109/L)

0.42 (0.30–0.60)

0.42 (0.32–0.62)

0.38 (0.27–0.55)

0.547

 Eosinophils (0.02–0.52*109/L)

0.08 (0.03–0.14)

0.09 (0.05–0.14)

0.03 (0.01–0.10)

0.343

 Basophils (0–0.06*109/L)

0.02 (0.01–0.03)

0.02 (0.01–0.03)

0.01 (0.00–0.02)

0.004

 Hemoglobin (130–175 g/L)

126.00 (115.00–133.25)

126.00 (117.50–134.00)

127.00 (111.50–132.50)

0.114

 Platelets (125–350*109/L)

236.00 (169.50–305.25)

251.00 (202.00–317.00)

186.00 (103.50– 249.00)

0.000

Coagulation function

    

 PT (9.2–15 s)

13.17 (12.30–14.22)

12.70 (12.15–13.59)

14.55 (13.40–16.53)

0.000

 INR (0.8–1.25)

1.1 (1.03–1.19)

1.06 (1.01–1.13)

1.21 (1.13–1.36)

0.000

 PT % (70–125)

94.3% (89.53%–98.48%)

96.4% (92.1%–99.3%)

87.60% (80.10%–92.15%)

0.000

 APTT (21–37 s)

27.54 (25.31–30.18)

25.99 (25.11–29.33)

29.25 (26.95–32.84)

0.057

 FIB (2–4 g/L)

3.26 (2.79–3.99)

3.23 (2.80–3.70)

3.62 (2.70–4.33)

0.780

 TT (10–20 s)

15.91 (14.94–15.83)

15.68 (14.79–16.69)

16.35 (15.69–17.47)

0.011

 D-Dimer (0–0.55 mg/L)

0.56 (0.33–1.12)

0.42 (0.28–0.79)

1.05 (0.68–5.90)

0.000

Blood biochemistry

    

 ALT (9–50 IU/L)

29.85 (16.60–52.63)

28.80 (15.75–50.15)

30.80 (19.00–58.30)

0.487

 AST (9–60 IU/L)

23.90 (17.20–36.60)

22.6 (16.7–32.03)

27.80 (19.30–40.55)

0.102

 TP (68–85 g/L)

62.60 (57.50–67.30)

63.95 (67.95– 58.85)

57.80 (52.80–63.15)

0.000

 ALB (40–50 g/L)

34.50 (30.30–38.00)

36.00 (32.88–39.10)

30.90 (27.60–33.65)

0.000

 GLB (20–35 g/L)

34.50 (30.30–38.00)

26.70 (25.20–29.60)

26.50 (23.90–31.40)

0.576

 Blood glucose (3.9–6.11 mmol/L)

5.22 (4.64–6.55)

5.06 (4.61–5.84)

6.15 (5.08–9.16)

0.002

 B–type natriuretic peptide (0–100 pg/mL)

11.05 (0.01–48.24)

0.01 (0.01–33.74)

40.55 (2.52–116.64)

0.052

 Serum creatinine (57–97 μmol/L)

66.70 (56.83–78.85)

67.35 (57.88–77.75)

65.35 (55.78–79.45)

0.402

 LDH(120–250 IU/L)

196.10 (164.80–278.70)

188.25 (162.13–219.33)

302.70 (198.90–479.00)

0.000

 Myoglobin (0–65 ng/mL)

7.58 (3.36–21.46)

5.13 (2.92–11.97)

25.14 (9.05–30.22)

0.022

 Troponin (0–0.04 ng/mL)

0.01 (0.01–0.01)

0.01 (0.01–0.01)

0.01 (0.01–0.05)

0.125

Infection related parameters

    

 PCT (0–0.05 ng/mL)

0.05 (0.03–0.12)

0.03 (0.03–0.07)

0.13 (0.07–0.21)

0.564

 CRP (0–4 mg/L)

7.25 (1.59–60.74)

4.22 (0.96–15.75)

64.74 (6.58–119.03)

0.000

  1. Data are median value (interquartile range)
  2. PT prothrombin time, INR international normalized ratio, APTT activated partial thromboplastin time, FIB fibrinogen, TT thrombin time, LDH lactate dehydrogenase, ALT alanine aminotransferase, AST aspartate aminotransferase, TP total protein, ALB albumin, GLB globulin, PCT procalcitonin, CRP C-reactive protein