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Fig.1 | Experimental Hematology & Oncology

Fig.1

From: Macrophage, the potential key mediator in CAR-T related CRS

Fig.1

Illustration of the role of macrophage in CRS. The CRS-related macrophage is mainly derived from myeloid. In CAR-T scenario, the infusion of CAR T cells initiated the mobilization of monocyte-macrophage lineage in myeloid. Once recruited to the colocalization of CAR T cells and tumor cells, the macrophages turned to activation and proliferation. The core cytokines in CRS were then secreted from the macrophage to the microenvironment, which was conducted by multiple mechanisms including the CD40-CD40L interaction with CAR T cells and a self-enhanced loop of catecholamine. And all these cytokines were then participating in the genesis and upsurge of CRS. Also, the underlying production of GM-CSF from CAR T cells was proved able to stimulate and enhance the mobilization and proliferation of monocyte-macrophage lineage, which unsurprisingly led to a self-amplified loop of the whole process of CRS. IFN interferon, GM-CSF Granulocyte-macrophage Colony Stimulating Factor, CAR chimeric antigen receptor

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