Fig. 5

Multi-omics signatures for recognizing of immune subtypes. a Heatmap for the featured mRNA (by random forest selecting) distribution in SVM classifier and three clusters. Heatmap for the CpG methylation sites, LncRNAs, miRNAs and proteins can be obtained in Fig. S14A-D. b Visualization with sankey diagram for the distribution alteration of patients in immunoscore groups, 3 clusters and SVM subtypes. c Kaplan–Meier OS curves grouped by SVM classifier in TCGA cohort. Comparison of immune scores (d), stromal scores (e), CD8 T cells (f), T cell dysfunction (g) (Wilcoxon signed rank test) and predicted response to immunotherapy (h) (Chi-squared test) between Type A and Type B based on SVM model in TCGA cohort. i Forest diagram for subtype analysis between Type A and Type B in independent cohorts and whole meta HCC dataset. ns: no significance, *P < 0.05, **P < 0.01, ***P < 0.001