Fig. 4

Regulation of immunomodulators and prediction of the response to the immune checkpoint blockade therapy. a Heatmap for the significant differential expression of immunomodulators. b CNV distribution of IFNG among three clusters. Each column represents the total proportion of each subtype and each color indicates different type of CNV (Chi-squared test). c Immune scores, and d scores of T cell dysfunction among three subtypes in TCGA-LIHC. e Prediction of immunotherapy responsiveness among three clusters in TCGA-LIHC by TIDE (Chi-squared test). ns: no significance, *P < 0.05, **P < 0.01, ***P < 0.001