Fig. 2

Prognostic evaluation of TME cells in HCC. a Network graph of TME cells’ interaction in HCC. The bubble color represents different prognostic effects: Red: high-risk TME cells, Blue: protective immune cells; The size of bubble indicates P-value, and bold edges means significant survival of TME cells (univariate COX regression, P < 0.05); The lines of network represent the correlations among TME cells (Spearman correlation). The thicker the line, the stronger the correlation. The red represents a positive correlation, and the light grey represents a negative correlation. b Prognostic analysis of each TME cell for each subtype. c Kaplan–Meier overall survival curves based on TME cell LASSO model. High risk and low risk group was divided by the optimal cutoff value by survminer package. d Distribution of TME immune risk scores based on TME cell LASSO model and e Kaplan–Meier OS curves among three subtypes. ns: no significance, *P < 0.05, **P < 0.01, ***P < 0.001