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Table 1 Patient characteristics

From: Dual EGFR blockade with cetuximab and erlotinib combined with anti-VEGF antibody bevacizumab in advanced solid tumors: a phase 1 dose escalation triplet combination trial

Characteristics

Number of patients n = 36, n (%)

Age (years)

 Median

54

 Range

(15–79)

Gender

 Male

14 (39%)

 Female

22 (61%)

Race

 White/Caucasian

28 (78%)

 Black/African-America

4 (11%)

 Other

4 (11%)

Smoking

 Active or history of smoking

18 (50%)

 Never smoker

18 (50%)

ECOG performance status

 0

1 (3%)

 1

30 (83%)

 2

5 (14%)

Tumor type

 Head and neck squamous cell carcinoma

10 (28%)

 Cervical cancer

10 (28%)

 Thyroid follicular carcinoma

4 (11%)

 Breast cancer

3 (8%)

 Pancreatic cancer

3 (8%)

 Salivary glands cancer

2 (6%)

 Bladder urothelial carcinoma

2 (6%)

 Sarcoma

1 (3%)

 Vulvar cancer

1 (3%)

 Squamous cell carcinoma of the skin

1 (3%)

Number of prior systemic therapies

 Median

3

 Range

1–10

Prior systemic treatment with anti-EGFR

8 (22%)

Prior systemic treatment with anti-VEGF

9 (25%)

Prior systemic treatment with anti-EGFR and anti-VEGF (sequential)

2 (6%)