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Fig. 3 | Experimental Hematology & Oncology

Fig. 3

From: The SMAC mimetic LCL-161 selectively targets JAK2V617F mutant cells

Fig. 3

LCL-161 preferentially decreases MPN colony formation. Methylcellulose colony formation of a, b whole bone marrow from JAK2V617F or wild-type mice and c, d peripheral blood mononuclear cells from JAK2V617F mutated MPN patients or normal controls with increasing concentrations of LCL-161 alone (a, c) or LCL-161 + 0.25 ng/ml TNFα (b, d). *P < 0.05, ***P < 0.001, unpaired t test

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