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Fig. 2 | Experimental Hematology & Oncology

Fig. 2

From: Gut microbiome and CAR-T therapy

Fig. 2

Butyrate produced by Akkermansia muciniphila would preferentially mount a pro-inflammatory immune response and suppress Tregs in the TME. This IL-12-mediated immune effector T-cell activation will boost ICI efficacy and secondarily enhance responses to CAR T-cells

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