Table 1 Strategies for safer CAR-T therapy
From: Development of molecular and pharmacological switches for chimeric antigen receptor T cells
Strategy | Mechanism |
|---|---|
Suicide gene | |
Combinational targeted activation | Two antigen recognitions are required to fully activate CAR-T cells [5] |
Inhibitory CAR-T cells | Recognition of normal cell induces inhibition of CAR-T cell activity [6] |
CAR modification | Modification of CAR molecules to identify constructs with less cytokine production activity but with preserved anti-tumor function [7] |
On/off switch for CAR-T cell | Dasatinib serves as an on/off switch for CAR-T cells [8] |