Fig. 1

Demonstrates the potential interactions between homozygotic SS form RBCs of SCD and the blood vessel wall endothelium. VEGF vascular endothelial growth factor, ET-1 endothelin-1, V-CAM-1 vascular-cell adhesion molecule-1, ICAM-1 intercellular adhesion molecule 1, NF-κβ nuclear factor-κβ, IL interleukin, TNF-α tumor necrosis factor-α