Table 1 Cell death in MCL cell lines, exposed to anti-CD20 antibody and PBMC pre-treated with ibrutinib

JeKo-1

Rituximab (1 µM)

Obinutuzumab (1 µM)

 0.1

0.49 ± 0.12

0.145

0.48 ± 0.00

0.003*

 0.5

0.25 ± 0.06

0.023*

0.40 ± 0.11

0.118

 1

0.20 ± 0.03

0.024*

0.17 ± 0.06

0.005*

 5

0.21 ± 0.02

0.012*

0.11 ± 0.01

0.008*

REC-1

Rituximab (1 µM)

Obinutuzumab (1 µM)

 0.1

0.71 ± 0.06

0.126

0.93 ± 0.03

0.222

 0.5

0.70 ± 0.03

0.056

0.86 ± 0.01

0.044*

 1

0.54 ± 0.11

0.152

0.79 ± 0.07

0.204

 5

0.27 ± 0.00

0.001*

0.39 ± 0.05

0.056