Table 2 The sensitivity, specificity, NPV and PPV for new markers measured in 85 DRE and 65 FV urine DNAs
From: An expanded biomarker panel for the detection of prostate cancer from urine DNA
Marker name | DNA type | No. Pos/No. cases | Sensitivity | 95% CI | No. Neg/No. controls | Specificity | 95% CI | PPV | NPV |
|---|---|---|---|---|---|---|---|---|---|
HOXA11as | DRE | '10/36 | 0.28 | (0.13, 0.42) | '43/49 | 0.88 | (0.79, 0.97) | 0.63 | 0.63 |
FV | '16/30 | 0.53 | (0.35, 0.71) | '29/35 | 0.83 | (0.70, 0.95) | 0.73 | 0.67 | |
KLK10 | DRE | '17/36 | 0.47 | (0.31, 0.64) | '44/49 | 0.9 | (0.81, 0.98) | 0.77 | 0.7 |
FV | '10/30 | 0.33 | (0.16, 0.50) | '29/35 | 0.83 | (0.70, 0.95) | 0.62 | 0.59 | |
GPR147 | DRE | '18/36 | 0.5 | (0.34, 0.66) | '41/49 | 0.84 | (0.73, 0.94) | 0.69 | 0.7 |
FV | '15/30 | 0.5 | (0.32, 0.68) | '24/35 | 0.69 | (0.53, 0.84) | 0.58 | 0.62 | |
GPR62 | DRE | '20/36 | 0.56 | (0.39, 0.72) | '32/49 | 0.65 | (0.52, 0.79) | 0.54 | 0.67 |
FV | '24/30 | 0.8 | (0.66, 0.94) | '24/35 | 0.69 | (0.53, 0.84) | 0.69 | 0.8 | |
HOXD4rc | DRE | '11/36 | 0.31 | (0.16, 0.46) | '41/49 | 0.84 | (0.73, 0.94) | 0.58 | 0.63 |
FV | '8/30 | 0.27 | (0.11, 0.42) | '29/35 | 0.83 | (0.70, 0.95) | 0.57 | 0.57 | |
HOXD3c | DRE | '23/36 | 0.64 | (0.48, 0.80) | '31/49 | 0.63 | (0.50, 0.77) | 0.56 | 0.71 |
FV | '26/30 | 0.87 | (0.75, 0.99) | '16/35 | 0.46 | (0.29, 0.62) | 0.58 | 0.81 | |
FRZB | DRE | '20/36 | 0.56 | (0.39, 0.72) | '33/49 | 0.67 | (0.54, 0.80) | 0.55 | 0.68 |
FV | '23/30 | 0.77 | (0.62, 0.92) | '26/35 | 0.74 | (0.60, 0.89) | 0.72 | 0.79 | |
GRASPrc | DRE | '14/36 | 0.39 | (0.23, 0.55) | '42/49 | 0.86 | (0.76, 0.96) | 0.67 | 0.66 |
FV | '13/30 | 0.43 | (0.26, 0.61) | '31/35 | 0.89 | (0.78, 0.99) | 0.77 | 0.65 | |
HOXBAS3 | DRE | '16/36 | 0.44 | (0.28, 0.61) | '41/49 | 0.84 | (0.73, 0.94) | 0.67 | 0.67 |
FV | '14/30 | 0.47 | (0.29, 0.65) | '32/35 | 0.91 | (0.82, 1.01) | 0.82 | 0.67 | |
HOXCrcAS3 | DRE | '7/36 | 0.19 | (0.07, 0.32) | '48/49 | 0.98 | (0.94, 1.02) | 0.87 | 0.63 |
FV | '6/30 | 0.2 | (0.06, 0.34) | '35/35 | 1 | (1.00, 1.00) | 1 | 0.59 | |
HOXD8rc | DRE | '8/36 | 0.22 | (0.09, 0.36) | '45/49 | 0.92 | (0.84, 1.00) | 0.67 | 0.62 |
FV | '10/30 | 0.33 | (0.16, 0.50) | '33/35 | 0.94 | (0.87, 1.02) | 0.82 | 0.62 | |
RASSF1 | DRE | '22/36 | 0.61 | (0.45, 0.77) | '33/49 | 0.67 | (0.54, 0.80) | 0.57 | 0.7 |
FV | '22/30 | 0.73 | (0.58, 0.89) | '26/35 | 0.74 | (0.60, 0.89) | 0.71 | 0.76 | |
SLC16A5rc | DRE | '12/36 | 0.33 | (0.18, 0.49) | '45/49 | 0.92 | (0.84, 1.00) | 0.75 | 0.65 |
FV | '11/30 | 0.37 | (0.19, 0.54) | '29/35 | 0.83 | (0.70, 0.95) | 0.65 | 0.61 |