Skip to main content

Advertisement

Table 2 The sensitivity, specificity, NPV and PPV for new markers measured in 85 DRE and 65 FV urine DNAs

From: An expanded biomarker panel for the detection of prostate cancer from urine DNA

Marker name DNA type No. Pos/No. cases Sensitivity 95% CI No. Neg/No. controls Specificity 95% CI PPV NPV
HOXA11as DRE '10/36 0.28 (0.13, 0.42) '43/49 0.88 (0.79, 0.97) 0.63 0.63
FV '16/30 0.53 (0.35, 0.71) '29/35 0.83 (0.70, 0.95) 0.73 0.67
KLK10 DRE '17/36 0.47 (0.31, 0.64) '44/49 0.9 (0.81, 0.98) 0.77 0.7
FV '10/30 0.33 (0.16, 0.50) '29/35 0.83 (0.70, 0.95) 0.62 0.59
GPR147 DRE '18/36 0.5 (0.34, 0.66) '41/49 0.84 (0.73, 0.94) 0.69 0.7
FV '15/30 0.5 (0.32, 0.68) '24/35 0.69 (0.53, 0.84) 0.58 0.62
GPR62 DRE '20/36 0.56 (0.39, 0.72) '32/49 0.65 (0.52, 0.79) 0.54 0.67
FV '24/30 0.8 (0.66, 0.94) '24/35 0.69 (0.53, 0.84) 0.69 0.8
HOXD4rc DRE '11/36 0.31 (0.16, 0.46) '41/49 0.84 (0.73, 0.94) 0.58 0.63
FV '8/30 0.27 (0.11, 0.42) '29/35 0.83 (0.70, 0.95) 0.57 0.57
HOXD3c DRE '23/36 0.64 (0.48, 0.80) '31/49 0.63 (0.50, 0.77) 0.56 0.71
FV '26/30 0.87 (0.75, 0.99) '16/35 0.46 (0.29, 0.62) 0.58 0.81
FRZB DRE '20/36 0.56 (0.39, 0.72) '33/49 0.67 (0.54, 0.80) 0.55 0.68
FV '23/30 0.77 (0.62, 0.92) '26/35 0.74 (0.60, 0.89) 0.72 0.79
GRASPrc DRE '14/36 0.39 (0.23, 0.55) '42/49 0.86 (0.76, 0.96) 0.67 0.66
FV '13/30 0.43 (0.26, 0.61) '31/35 0.89 (0.78, 0.99) 0.77 0.65
HOXBAS3 DRE '16/36 0.44 (0.28, 0.61) '41/49 0.84 (0.73, 0.94) 0.67 0.67
FV '14/30 0.47 (0.29, 0.65) '32/35 0.91 (0.82, 1.01) 0.82 0.67
HOXCrcAS3 DRE '7/36 0.19 (0.07, 0.32) '48/49 0.98 (0.94, 1.02) 0.87 0.63
FV '6/30 0.2 (0.06, 0.34) '35/35 1 (1.00, 1.00) 1 0.59
HOXD8rc DRE '8/36 0.22 (0.09, 0.36) '45/49 0.92 (0.84, 1.00) 0.67 0.62
FV '10/30 0.33 (0.16, 0.50) '33/35 0.94 (0.87, 1.02) 0.82 0.62
RASSF1 DRE '22/36 0.61 (0.45, 0.77) '33/49 0.67 (0.54, 0.80) 0.57 0.7
FV '22/30 0.73 (0.58, 0.89) '26/35 0.74 (0.60, 0.89) 0.71 0.76
SLC16A5rc DRE '12/36 0.33 (0.18, 0.49) '45/49 0.92 (0.84, 1.00) 0.75 0.65
FV '11/30 0.37 (0.19, 0.54) '29/35 0.83 (0.70, 0.95) 0.65 0.61