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Table 2 Factors affecting relapse free and overall survival in 141 non-transplant AML patients

From: Cytogenetics and FLT3-ITD mutation predict clinical outcomes in non transplant patients with acute myeloid leukemia

Factors Overall study population Completed consolidation therapy AML with normal karyotype AML with normal karyotype and completed consolidation therapy Supportive care
mRFS (Mo)
N = 73
p mOS (Mo)
N = 141
p mRFS (Mo)
N = 41
p mOS (Mo)
N = 41
p mRFS (Mo)
N = 42
p mOS (Mo)
N = 83
p mRFS (Mo)
N = 22
p mOS (Mo)
N = 23
p mOS (Mo)
N = 30
p
Age (years)
 < 60 11 0.235 13 0.007 14 0.196 30 0.436 12 0.734 17 0.003 18 0.504 31 0.957 3 0.781
 ≥ 60 22 4 NR NR 22 4 NR NR 2
White blood cell count
 < 100,000/μL 12 0.004 11 0.007 48 0.074 33 0.013 18 0.003 15 0.008 48 0.029 63 0.017 2 0.12
 > 100,000/μL 6 7 14 17 6 5 6 23 1
Cytogenetic risk
 Favorable 14 0.141 18 0.000 14 0.044 25 0.007 0.236
 Intermediate 12 11 22 31 3
 Unfavorable 9 4 9 14 2
Gene mutation
 FLT3-ITD+ 2 0.047 9 0.047 15 0.518 16 0.402 1 0.000 7 0.051 0.156 0.397 1 0.072
 NPM1+ 18 15 51 63 18 15 51 63 2
 FLT3-ITD+ and NPM1+ 4 5 22 23 4 5 22 23 1
 CEBPA+ 17 22 NR 23 17 22 NR 23 16
 No mutation 10 7 14 30 11 9 11 31 2
FLT3-ITD mutation
 Yes 5 0.04 7 0.076 15 0.686 16 0.131 1 0.000 7 0.074 1 0.416
 No 12 9 18 31 13 13 22   31   2
NPM1 mutation
 Yes 18 0.16 15 0.178 51 0.146 63 0.222 18 0.115 15 0.27 51 0.061 63 0.161 1 0.665
 No 11 9 14 30 12 11 14 31 2
CEBPA mutation
 Yes 13 0.439 19 0.149 NR 0.411 23 0.834 17 0.417 19 0.362 NR 0.601 23 0.547 16 0.016
 No 11 9 14 31 12 11 22 33 2
Consolidation regimen
 HiDAC 12 0.257 31 0.535 1 0.529 31 0.208 12 0.188 31 0.273 12 0.203 31 0.281  
 IDAC 14 25 14 25 22 31 22 31
 Azacitidine NR NR NR NR NR NR NR NR
Consolidation regimen
 HiDAC 12 0.683 31 0.803 12 0.788 31 0.557 12 0.25 31 0.267 12 0.226 31 0.267  
 IDAC 14 25 14 25 22 31 22 31
Complete remission (CR)
 CR   17 0.000    23 0.005  
 No CR 6 9
  1. mRFS median relapse free survival, mOS median overall survival, NR not reach, NA not available