Fig. 1
From: Methylome of human senescent hematopoietic progenitors
Multiresolution chromatin confirmation. Multi-resolution chromatin conformation inference for non-senescent (red/gray) and senescent (yellow/gray) HSPCs across chromosome 6 reveals representative genome-wide changes in open/closed compartments between cell types. The 50 kb resolution shows widespread focal chromatin accessibility across chromosome 6, encompassing regions rich in TEs. Open chromatin (negative eigenvalues); closed chromatin (positive eigenvalues)