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Fig. 1 | Experimental Hematology & Oncology

Fig. 1

From: Induction of anti-leukemic responses by stimulation of leukemic CD3+ cells with allogeneic stimulator cells

Fig. 1

a Lysis (lytic units/106 cells) of CD3-cells observed in CD3+ cells incubated with mitomycin-treated healthy donor allogeneic PBMC (allostimulated CD3+ cells) or syngeneic CD3-cells (autologous stimulated CD3+ cells). Open circles represent the 4 patient samples that demonstrated spontaneous ability to lyse CD3-cells and their corresponding ability to lyse once allostimulated. (Mann–Whitney U = 248, n1 = n2 = 42, P < 0.05 two-tailed). b Lysis (lytic units/106 cells) of CD3-cells observed by diagnosis. c Stimulation index of allostimulated CD3+ cells separated into greater than 50% peripheral blasts, between 20 and 50% peripheral blasts, or less than 20% peripheral blasts. d Lysis (lytic units/106 cells) of CD3-cells observed in allostimulated CD3+ cells separated into greater than 50% peripheral blasts, between 20 and 50% peripheral blasts, or less than 20% peripheral blasts. e Percentage of CD4+ cells expressing Granzyme A, CD4+ Granzyme B, and CD4+ Perforin on the leukemic patient CD3+ population that demonstrated lysis and the population that did not lyse (mean ± standard deviation (s.d.)). f Percentage of cells expressing CD8+CD39+, CD4+ TCRγδ, and CD4+CD39+ on the leukemic patient CD3+ population that demonstrated lysis and the population that did not lyse (mean ± S.D.). *P < 0.05. NS not significant. Horizontal bars in (a) and (b) signify mean

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