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Table 1 Summary of cases (n = 91), part I, part II, part III

From: Bullous hemorrhagic dermatosis is an under-recognized side effect of full dose low-molecular weight heparin: a case report and review of the literature

References Age Gender Agent Days to lesion Location Intervention Days to resolution
Part I
 [1] 62 F Enoxaparin Unknown Buttock AC changed to warfarin 14
 [1] 32 M Enoxaparin 14 Lower extremities AC discontinued 7
 [2] 75 M Dalteparin 5 Hands and groin AC changed to coumadin, died of IC 14 days later Death
 [2] 82 F Tinzaparin 6 Extremities AC discontinued 10
 [2] 64 M Heparin Calcium 21 Forearms and ankles AC continued Yes, unknown
 [3] 72 F Enoxaparin 2 Abdomen and upper extremities AC changed to oral after planned intervention 14
 [3] 57 M Enoxaparin 3 Abdomen and upper and lower extremities Unknown Unknown
 [4] 88 M Enoxaparin then warfarin 14 Left arm and ankle AC discontinued 14
 [5] 51 Unknown Enoxaparin then tinzaparin 2 Upper and lower extremities, abdomen AC discontinued Unknown
 [6] 86 M Enoxaparin 1 Trunk, extremities AC continued 30
 [6] 87 M Enoxaparin 5 Limbs and hands AC continued 21
 [6] 73 F Bemiparin then Enoxaparin 1 Lower extremities Changed to rivaroxaban, died 10 days later Death
 [6] 72 M Bemiparin 30 Trunk, legs AC continued 21
 [6] 82 M Enoxaparin 3 Arms AC continued 21
 [7] 68 M Enoxaparin 8 Hand, neck, and face Unknown 14
 [7] 78 M Enoxaparin 10 Knees and forearm AC continued 14
 [8] 85 M Enoxaparin 3 Torso and legs AC discontinued Unknown
 [9] 73 M Enoxaparin 14 Upper extremities AC continued 14
 [10] 77 M Enoxaparin 3 Trunk, right hand AC discontinued 2
 [10] 94 M Tinzaparin 15 Trunk, limbs AC discontinued 10
 [11] 59 F Enoxaparin 30 Dorsal hand AC continued 4
 [12] 68 M Enoxaparin 1 Feet, leg, neck, hands dorsum AC discontinued Unknown
 [12] 77 M Enoxaparin 8 Dorsum of feet, dorsum of hands AC discontinued Unknown
 [13] 88 F Enoxaparin 5 Legs AC changed to warfarin Unknown
 [14] 87 F Enoxaparin 10 Knees, forearms, elbows Unknown 14
 [15] 71 M Enoxaparin 2 Abdomen AC discontinued 7
 [16] 90 M Enoxaparin 8 Left arm and ankle AC continued 14
 [17] 73 M Enoxaparin 6 Left palm AC continued 14
Part II
 [18] 63 M Enoxaparin 12 Lower extremities AC continued 3
 [18] 74 M Enoxaparin 13 Lower extremities AC continued 3
 [19] 83 M Warfarin + UFH 5 Arms, flank, thighs Heparin discontinued Yes, unknown
 [20] 77 M Enoxaparin 5 Unknown Changed to dabigatran 14
 [21] 82 F Warfarin 10 Extremities Changed to enoxaparin Worsening lesions, resolved after all AC stopped
 [22] 90 M Enoxaparin 8 Ankle and wrist AC continued 14
 [22] 65 M Enoxaparin 9 Lower and upper extremities Changed to tinzaparin as lesions persisted for 6 weeks on enoxaparin 14
 [22] 64 M Enoxaparin 7 Lower and upper extremities AC continued 21
 [22] 89 M Enoxaparin 10 Lower and upper extremities scalp and back AC discontinued 21
 [22] 74 M Enoxaparin 20 Hand and leg AC discontinued 14
 [23] 71 M Enoxaparin 14 Forearms, hands, knees AC continued Persisting lesions for 6 months, resolved after AC stopped
 [24] 64 M Enoxaparin 5 Arms and hands Dose reduced 14
 [25] 74 M Enoxaparin 5 Upper and lower extremities, abdomen AC discontinued 7
 [26] 52 M Enoxaparin 7 Lower and upper extremities AC continued 3
 [27] 77 F Enoxaparin 15 Limbs AC continued 14
 [28] 77 F Enoxaparin 5 Hands and shins AC continued, fatal ICH 4 weeks later 12
 [29] 72 M Enoxaparin 7 Arm and legs AC changed to UFH 7
 [30] 59 F Enoxaparin 270 Legs AC changed to fondaparinux then rivaroxaban Unknown
 [30] 51 F Fondaparinux Unknown Legs AC changed to rivaroxaban 3
 [31] 75 F Enoxaparin 3 Arms, hands, feet AC held, lesions resolved, AC restarted and lesions re-appeared, improved with steroids, patient had past history of bullous pemphigoid 28
Part III
 [32] 60 M UFH 5 Limbs and trunk AC continued Unknown
 [32] 68 F UFH then enoxaparin 7 Abdomen, hands, feet AC changed to rivaroxaban 21
 [32] 64 M Enoxaparin, warfarin 9 Lower and upper extremities AC discontinued 30
 [32] 38 F UFH 7 Chest and ankle AC discontinued 7
 [32] 72 F Enoxaparin 2 Forearm AC discontinued 2
 Ref. [33];
Case series of 37 cases, 1985–2015
77.4 M 20
F 17
LMWH
Fondaparinux
Sodic heparin
Calcic heparin
8.8 Limbs and trunk AC discontinued in 34 cases
AC continued in 1 case
Unknown in 2 cases
Unknown
 Case currently reported 62 M Enoxaparin 7 Calf and hands AC continued with worsening lesions, after 4 months changed to apixaban 21 after change to apixaban
  1. AC anticoagulation, F female, ICH intracranial hemorrhage, LMWH low molecular weight heparin, M male, UFH unfractionated heparin