Bone marrow transplant-associated thrombotic microangiopathy without peripheral blood schistocytes: a case report and review of the literature

Table 1 Summary of TA-TMA diagnostic criteria

Diagnostic criteria	Ho [7]	Ruutu [8]	Cho [9]	Jodele [21]
Schistocytes^a	✓	✓	✓	✓^b
Elevated LDH	✓	✓	✓	✓
Renal and/or neurologic dysfunction	✓			✓^c
Thrombocytopenia		✓	✓	✓
Anemia		✓	✓	✓
Low haptoglobin		✓	✓
Normal PT/PTT	✓	✓	✓
Negative Coombs test	✓		✓
Terminal complement activation				✓

^aHo and Cho defined increased schistocytes as ≥ 2/HPF. Ruutu defined ≥ 8/HPF as the threshold suggestive of TA-TMA
^bJodele noted that histologic evidence of microangiopathy on a tissue specimen may exist in the absence of peripheral blood schistocytosis and considered this finding sufficient for a diagnosis of TA-TMA even in the absence of other any other suggestive clinical features
^cUrinalysis protein concentration of ≥ 30 mg/dL and/or hypertension considered more reliable than serum creatinine as evidence of renal dysfunction

ISSN: 2162-3619