From: Phase 2 study of everolimus for relapsed or refractory classical Hodgkin lymphoma
AE | Any grade | Grade 1/2 | Grade 3/4 |
---|---|---|---|
Any | 56 (98.2) | 21 (36.8) | 35 (61.4) |
Fatigue | 33 (57.9) | 33 (57.9) | 0 |
Thrombocytopenia | 28 (49.1) | 16 (28.1) | 12 (21.1) |
Cough | 28 (49.1) | 27 (47.4) | 1 (1.8) |
Rash | 22 (38.6) | 21 (36.8) | 1 (1.8) |
Anemia | 19 (33.3) | 11 (19.3) | 8 (14.0) |
Pyrexia | 19 (33.3) | 19 (33.3) | 0 |
Dyspnea | 17 (29.8) | 14 (24.6) | 3 (5.3) |
Back pain | 16 (28.1) | 14 (24.6) | 2 (3.5) |
Diarrhea | 16 (28.1) | 15 (26.3) | 1 (1.8) |
Stomatitis | 14 (24.6) | 12 (21.1) | 2 (3.5) |
Upper respiratory tract infection | 14 (24.6) | 13 (22.8) | 1 (1.8) |
Headache | 13 (22.8) | 12 (21.1) | 1 (1.8) |
Nausea | 14 (24.6) | 14 (24.6) | 0 |
Vomiting | 13 (22.8) | 13 (22.8) | 0 |
Peripheral edema | 12 (21.1) | 12 (21.1) | 0 |
Hyperglycemia | 10 (17.5) | 7 (12.3) | 3 (5.3) |
Pruritus | 12 (21.1) | 12 (21.1) | 0 |
Abdominal pain | 9 (15.8) | 9 (15.8) | 0 |
Arthralgia | 9 (15.8) | 9 (15.8) | 0 |
Aspartate aminotransferase increased | 9 (15.8) | 8 (14.0) | 1 (1.8) |
Muscle spasms | 9 (15.8) | 9 (15.8) | 0 |
Neuropathy peripheral | 9 (15.8) | 9 (15.8) | 0 |
Oropharyngeal pain | 11 (19.3) | 11 (19.3) | 0 |
Acne | 8 (14.0) | 8 (14.0) | 0 |
Alanine aminotransferase increased | 8 (14.0) | 7 (12.3) | 1 (1.8) |
Dysgeusia | 8 (14.0) | 8 (14.0) | 0 |
Epistaxis | 8 (14.0) | 8 (14.0) | 0 |
Neutropenia | 8 (14.0) | 3 (5.3) | 5 (8.8) |
Pain | 8 (14.0) | 7 (12.3) | 1 (1.8) |
Pain in extremity | 8 (14.0) | 7 (12.3) | 1 (1.8) |
Sinusitis | 10 (17.5) | 10 (17.5) | 0 |
Blood alkaline phosphatase increased | 9 (15.8) | 7 (12.3) | 2 (3.5) |
Bronchitis | 7 (12.3) | 7 (12.3) | 0 |
Hypertriglyceridemia | 7 (12.3) | 5 (8.8) | 2 (3.5) |
Pneumonia | 7 (12.3) | 3 (5.3) | 4 (7.0) |
Blood lactate dehydrogenase increased | 6 (10.5) | 6 (10.5) | 0 |
Decreased appetite | 7 (12.3) | 7 (12.3) | 0 |
Hypercholesterolemia | 6 (10.5) | 6 (10.5) | 0 |
Hypokalemia | 6 (10.5) | 5 (8.8) | 1 (1.8) |
Hypophosphatemia | 7 (12.3) | 2 (3.5) | 5 (8.8) |
Insomnia | 6 (10.5) | 6 (10.5) | 0 |
Night sweats | 6 (10.5) | 6 (10.5) | 0 |
Pleural effusion | 6 (10.5) | 4 (7.0) | 2 (3.5) |
Pneumonitis | 6 (10.5) | 6 (10.5) | 0 |
Weight decreased | 7 (12.3) | 7 (12.3) | 0 |