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Table 2 Association between the expression of miR-130b/301b and putative direct target genes in TCGA-PRAD

From: An integrated view of the role of miR-130b/301b miRNA cluster in prostate cancer

Gene

PMID

Role in PrCa

miR-130b

miR-301b

r

p value

r

p value

PPARGC1A

23868745

TSG? (PMC4884178)

− 0.3571

< 0.0001

− 0.3109

< 0.0001

TP63 a

24398967

TSG

− 0.3313

< 0.0001

− 0.2286

< 0.0001

NDRG2 b

27327120

TSG

− 0.2985

< 0.0001

− 0.2427

< 0.0001

SLC8A1 c

26489476

TSG

− 0.2884

< 0.0001

− 0.3174

< 0.0001

PARVA c

26489476

TSG

− 0.2846

< 0.0001

− 0.3113

< 0.0001

SMAD4

24220575

TSG

− 0.2240

< 0.0001

− 0.2151

0.0002

ZBTB4

24220575

TSG

− 0.2231

< 0.0001

− 0.2829

< 0.0001

ITGB1

24498407

TSG

− 0.2119

< 0.0001

− 0.1995

0.0006

STAT3

24040078

OG

− 0.1423

0.0009

− 0.2049

0.0004

ZEB1

22847613

OG

− 0.1338

0.0018

− 0.2058

0.0004

FMR1

24021279

unknown

− 0.1250

0.0035

− 0.1380

0.0175

CSF1

22005523

OG

− 0.1190

0.0055

− 0.1904

0.001

PTEN

24220575

TSG

− 0.1174

0.0062

− 0.1072

0.0654

MMP2b

25154741

OG

− 0.1094

0.0108

− 0.1286

0.027

PPARG

21135128

TSG

− 0.1072

0.0125

− 0.0358

0.5397

PDGFRA

22995917

OG

− 0.1041

0.0152

− 0.1640

0.0047

UVRAG

22228303

TSG

− 0.0812

0.0585

− 0.0984

0.0909

RUNX3

20176475

TSG

− 0.0220

0.6099

− 0.1161

0.046

ARb

28192399

TSG

− 0.0201

0.6405

− 0.0772

0.1856

DEDD2b

27307749

TSG

0.0080

0.8522

0.0418

0.4733

DICER1

23392577

unknown

0.1111

0.0096

0.0297

0.6112

TP53INP1

18974142

OG

0.2378

< 0.0001

0.1746

0.0026

LMNB1 b

28166834

OG

0.2404

< 0.0001

0.2071

0.0003

CCNA2

24681352

OG

0.2947

< 0.0001

0.2004

0.0005

  1. Correlation between miRNAs and validated mRNA targets gene expression. For each target gene the role in PrCa, the literature reference (PMID) and the correlation r and p value are shown
  2. Qualifiers in column 1 indicate: amiR-301b direct target with strong experimental evidence assigned by TarBase. DNMT1 was listed by TarBase but not included in this list since the referenced article demonstrates the absence of effect of miR-301b on DNMT1
  3. bDirect target genes with experimental validation in PrCa
  4. cDirect Targets predicted in PrCa. Absence of qualifier in column one indicates directed targets with strong experimental evidence assigned. TarBase does not identify targets for miR-130b/301b in PrCa. Correlations with p < 0.0001 are highlighted in italics