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Table 1 miR-130b/301b expression in PrCa datasets

From: An integrated view of the role of miR-130b/301b miRNA cluster in prostate cancer

Repository

Disease condition

Sample type

miR

Deregulation

Fold change

p value

PMID

GSE65061

Early/late recurrence

FFPE tissue

301b

UP4

1.7

0.026

25760964

GSE26245

Recurrent/non-recurrent

FFPE tissue

130b

UP4

1.2

0.024

21703393

GSE26247

Recurrent/non-recurrent

FFPE tissue

130b

UP4

1.3

0.017

21703393

Personal communication

Metastatic/primary tumor

Frozen tissue

130b

UP4

1.6

NA

21765474

GSE35813

PC-3/RWPE-1

Cell lines

130b and 301b

UP4

1.7 and 1.5

0.011 and 0.0091

22982408

GSE80400

Tumor/normal

Frozen tissue

130b

UP4

1.9

0.14

26041889

GSE21032, GSE21036, E-TABM-794

Tumor/normal

Recurrent/non-recurrent

Frozen tissue

130b

UP3

NA

NA

NA

0.004

26489476

GSE34933, GSE21032, GSE26367

Tumor/normal

Frozen and FFPE tissue

130b

UP3

NA

0.00000035

27179774

GSE21036 (PMID 20579941)

Primary tumor/normal

Metastatic/primary tumor

Metastatic tumor/normal

Frozen tissue

130b

UP3

1.5

1.7

2.6

< 0.0001

 = 0.0002

 0.0001

28192399

GSE55323, GSE26245, GSE26247, GSE65061, GSE62610, GSE46738

Recurrent/non-recurrent

Frozen and FFPE tissue

301b

UP3

NA

0.0066

28651018

GSE36803

Tumor/normal

Frozen tissue

130b

UP2

< 1.5

0.0019

23233736

NA

Tumor/normal

FFPE tissue

130b

UP2

2.2

0.02

27120795

NA

Resistant/sensitive to docetaxel

Cell lines

301b

UP1

2.2

0.002

24714754

GSE14857

Tumor/normal

Frozen tissue

130b

UP1

1.5

0.0006

19676045

E-TABM-794

Tumor/normal

Frozen tissue

130b and 301b

UP1

> 1.5

< 0.05

21765474

NA

PrCa patients/Normal control individuals

PrCa metastatic/PrCa localized patients

Plasma

130b

UP1

4.7

6.1

0.034

0.007

22240788

E-MTAB-408

Primary tumor/BPH

Frozen tissue

130b

UP1

2.00

0.00019

22266859

E-MTAB-408

CRPCs/BPH

Frozen tissue

130b

UP1

2.5

0.011

22266859

NA

C4-2B/RWPE-1

C4-2B/RWPE1 derived exosomes

Cell lines

130b

UP1

~ 2,

3.7

< 0.05

24715691

GSE62610

Recurrent/non-recurrent

FFPE tissue

301b

UP1

2

0.025

25416653

NA

Exosomes/cell line

Cell lines

130b

UP1

8.6

NA

27102850

NA

Short/long overall survival

FFPE tissue

301b

UP1

NA

0.029

27307749

NA

Hypoxia/normoxia

Cell lline

301b

UP1

> 2

NA

27327120

NA

Patients/healthy donors

Exosomes

130b

UP1

NA

0.0021

28192399

NA

Recurrent/non-recurrent

Tissue

130b

UP1

NA

0.018

28192399

NA

After/before docetaxel

Plasma and serum

301b

UP1

1.6

0.04

24714754

GSE46738

High/Low pre-operatory PSA levels

FFPE tissue

130b and 301b

DOWN and UP1

− 1.3 and 1.2

< 0.049 and < 0.003

25663948

GSE55323

Recurrent/non-recurrent

Tissue

301b

DOWN4

− 1.2

0.017

24967583

NA

Tumor/normal

FFPE tissue

130b

DOWN1

NA

< 0.0001

25154741

NA

Gleason 4 or 5/gleason 3

Recurrent/non-recurrent

Serum

130b

DOWN1

NA

< 0.05

25874774

GSE52955

Tumor/normal

Frozen tissue

130b and 301b

DOWN1

NA

< 0.0001 and 0.0014

28166834

  1. Disease condition and sample type are named according to the original study. References to the publications are presented as PMID. Data repository IDs: GSE corresponds to data deposited in Gene Expression Omnibus (GEO), and E-XXXX-XXX corresponds to data stored in Array Express. The fold change in expression between the conditions with its correlative p value were obtained from diverse sources which are indicated with superscript numbers in column “Change” as follows: 1. Identified and selected by the original publication, 2. Identified but not selected by the original publication, 3. Identified by analysis of the original study by others, 4. Identified in the present study by analysis of the original report