Fig. 1

Genomic and epigenomic context of the human miR-130b/301b gene cluster. a Sequence alignment of the miR-130b/301b gene cluster. miRNAs precursor (hsa-mirs) and mature miRNAs (hsa-miRs) are indicated. Sequences were retrieved from miRBase and the alignment was performed in SeaView using CLUSTALW with default parameters. b Genomic view of the miR-130b/301b gene cluster region in UCSC Genome browser (GRCh37/hg19) centered at the transcription star point of the di-cistronic transcript. Several ENCODE tracks are displayed (see the text for explanation). c Co-expression of miR-130b and miR-301b in prostate clinical samples of TCGA-PRAD, including normal and tumor tissue. Correlation between the levels of miR-301b (x axis) and miR-130b (y axis) of the TCGA-PRAD cohort. n = 294 (samples that report expression data for miR-301b). Data was obtained from RNA-seq of small RNAs downloaded from UCSC Xena Browser and is expressed in reads per million (RPM). The non-parametric Spearman correlation coefficient (r) is indicated