Fig. 4

PRL-3 inhibitors reduced survival in cHL cell lines. a, b 48 h treatment with PRL-3 inhibitors reduced proliferation in a L1236 and b HDLM2 as measured by CellTiter-Glo^®. Figure shows one representative of three independent experiments. Error bars represent ± 1 SD of triplicates. c, d Analog 3 (100 µM), PRL-3 inhibitor I (40 µM), and thienopyridone (10 µM) treatment for 48 h induced apoptosis in c L1236 and d HDLM2. Bars represent percent viable cells from one of three independent experiments with similar results. Error bars represent + 1 SD duplicates. Viability was determined by annexin V-FITC/propidium iodide using flow cytometry. *p < 0.05. ns not significant