Adult acute precursor B-cell lymphoblastic leukemia presenting as hypercalcemia and osteolytic bone lesions

Table 1 published case reports concerning B-ALL, osteolysis and hypercalcaemia

Author	Patient	Diagnosis	Osteolytic lesions	Mechanism
Chung [4]	Male 35 years	B-ALL Burkitt type	Left mandibula	PTHrP elevated
Seymour [7]	Female 65 years	B-ALL relapse	Multiple lesions	PTHrP nl
Seymour [7]	Female 44 years	B-ALL	Mulitple lesions	PTHrP nl
Kaiafa [6]	Male 24 years	Pre-B ALL relapse with lineage switch	Multiple lesions	PTHrP nl PTH low 1,25(OH)D nl
Verma [8]	Female 27 years	Pre-B ALL	Multiple skull lesions	N/A
Fukasawa [5]	Female 53 years	Pre-B ALL	Multiple lesions	PTH low PTHrP nl 1,25(OH)D low TNF-α elevated IL-6 elevated Solube IL-2 elevated

B-ALL acute B-cell lymphoblastic leukemia, PTHrP parathyroid hormone related protein, PTH parathyroid related hormone, TNF - α tumor necrosis factor alpha, IL6 interleukin 6, nl normal, N/A not available

ISSN: 2162-3619