Table 2 Quantitative sensory testing over time

C-fibers

 Warm detection threshold (WDT)

  Baseline

n = 119

n = 55

n = 64

   Test-area °C (range)

12.3 (1.1 to 18.0)

12.6 (1.3 to 18.0)

12.1 (1.1 to 18.0)

   Reference-area °C (range)

1.2 (0.5 to 22.8)

1.2 (0.5 to 22.8)

1.2 (0.5 to 17.6)

After 15 Interventions

n = 87

n = 40

n = 47

   Test-area °C (range)

10.4 (1.3 to 18.0)

9.5 (1.3 to 18.0)

11.0 (2.7 to 18.0)

   Reference-area °C (range)

1.3 (0.5 to 15.8)

1.3 (0.5 to 8.8)

1.3 (0.5 to 15.8)

Difference

n = 87

n = 40

n = 47

   Test-area Δ °C (range)

−0.7 (−13.1 to 16.9)

−1.1 (−13.1 to 6.2)

−0.1 (−10.0 to 16.9)

   Reference-area Δ °C (range)

0.0 (−22.2 to 2.2)

0.0 (−22.2 to 2.2)

0.0 (−16.5 to 2.0)

 Heat pain threshold (HPT)

  Baseline

n = 129

n = 55

n = 64

   Test-area °C (range)

48.6 (34.9 to 50.0)

48.7 (34.9 to 50.0)

48.3 (39.2 to 50.0)

   Reference-area °C (range)

44.7 (33.8 to 50.0)

44.7 (33.9 to 49.5)

44.7 (33.8 to 50.0)

After 15 Interventions

n = 87

n = 40

n = 47

   Test-area °C (range)

48.5 (37.4 to 50.0)

48.1 (37.4 to 50.0)

48.7 (39.9 to 50.0)

   Reference-area °C (range)

44.9 (33.8 to 50.0)

44.8 (33.9 to 50.0)

45.2 (33.8 to 50.0)

Difference

n = 85

n = 38

n = 47

   Test-area Δ °C (range)

0.0 (−7.2 to 8.94)

−0.04 (−3.93 to 3.57)

0.0 (−3.34 to 3.60)

   Reference-area Δ °C (range)

0.0 (−4.4 to 0.6)

0.0 (−0.12 to 4.23)

0.0 (−0.51 to 2.12)

Aδ-fibers

 Cold detection threshold (CDT)

  Baseline

n = 110

n = 56

n = 64

   Test-area °C (range)

−7.8 (−32.0 to 1.7)

−7.6 (−32.0 to −1.7)

−8.4 (−32.0 to −1.9)

   Reference-area °C (range)

−1.2 (−21.9 to 0.5)

−1.1 (−9.7 to −0.5)

−1.4 (-21.9 to −0.5)

After 15 Interventions

n = 88

n = 41

n = 47

   Test-area °C (range)

−6.8 (−32.0 to −1.3)

−6.6 (−32.0 to −1.3)

−6.9 (−32.0 to −1.6)

   Reference-area °C (range)

−1.3 (−21.9 to 0.5)

−1.1 (−6.8 to −0.47)

−1.4 (−21.9 to −0.5)

Difference

n = 85

n = 38

n = 47

   Test-area Δ °C (range)

0.7 (−11.1 to 26.9)

1.1 (−10.1 to 24.9)

0.7 (−11.1 to 26.9)

   Reference-area Δ °C (range)

0.0 (−4.0 to 6.7)

0.0 −0.3 to 6.7)

0.0 (4.0 to 3.9)

Aβ-fibers

 Mechanical detection threshold (MDT)

  Baseline

n = 110

n = 56

n = 64

   Test-area mN (range)

13.9 (0.2 to 724)

12.6 (0.9 to 724)

16.6 (0.2 to 223)

   Reference-area mN (range)

0.2 (0.2 to 6.1)

0.2 (0.2 to 6.1)

0.2 (0.2 to 4.6)

After 15 Interventions

n = 88

n = 41

n = 47

   Test-area mN (range)

17.8 (0.3 to 724)

19.7 (0.3 to 724)

17.2 (1.3 to 724)

   Reference-area mN (range)

0.2 (0.2 to 11.3)

0.2 (0.2 to 11.3)

0.2 (0.2 to 4.6)

Difference

n = 85

n = 38

n = 47

   Test-area mN (range)

0.0 (−174 to 501)

0.8 (−174 to 207)

−3.4 (−105 to 501)

   Reference-area mN (range)

0.0 (−0.5 to 4.8)

0.0 (−0.02 to 4.8)

0.0 (−0.5 to 0.2)