Fig. 1

Representative CT scan images of target lesions showing response to dabrafenib monotherapy and dabrafenib and trametinib combination. Patient started treatment and showed response at the first 3 monthly CT scan (b, f) in all target lesions compared to the baseline (a, e). At the second 3 monthly CT scan the pelvic mass showed increased size (panel c, indicated by straight red line) compared to baseline while pulmonary metastases showed maintained response (panel g, representative image). Introduction of trametinib halted further progression of the pelvic mass (panel d) and induced further regression of the pulmonary metastases (panel h) suggesting that MEK inhibition can synergize and revert resistance to BRAF targeting agents in endometrial cancer harboring BRAF V600F mutation