Long noncoding RNAs: pivotal regulators in acute myeloid leukemia

Table 1 LncRNAs in AML

LncRNAs	Classification	Function	Target genes	Reference
RUNXOR	Sense	Be involved in chromosomal translocation	RUNX1	[13]
HOTAIRM1	Antisense	Regulate myeloid differentiation and cell cycle enhance the autophagy pathway regulates chromatin state and architecture	HOXA1, HOXA4, CD11b and CD18 miR-20a/106b and miR-125b	[14–17]
HOXA-AS2	Antisense	Act as an apoptosis repressor	Unknown	[18]
PU.1-AS	Antisense	Inhibit the translation of PU.1	PU.1	[19]
WT1-AS	Antisense	Control WT1 expression	WT1	[20]
EGO	Intronic	Regulate MBP and EDN expression	MBP and EDN	[22]
IRAIN	Intronic	Be engaged in long-range intra chromosomal interactions	IGF1R	[23]
BGL3	Intergenic	Sensitize leukemic cells to undergo apoptosis	miR-17, miR-93, miR-20a, miR-20b, miR-106a and miR-106b	[24]
CCAT1	Intergenic	Repress monocytic differentiation and promote cell growth	miR-155	[25]
CCDC26	Intergenic	Control the growth of AML cells	c-Kit	[26]
HOTAIR	Intergenic	Induce cell growth and inhibit apoptosis	miR-193a and c-Kit	[27]
NEAT1	Intergenic	Regulate ATRA-induced myeloid differentiation	Unknown in AML	[28]
PVT1	Intergenic	Regulate proliferation of promyelocytes	MYC	[21]
UCA1	Intergenic	Sustain proliferation of AML cells	p27kip1	[29]
PVT1-NSMCE2	Fusion	Unknown	Unknown	[12]
BF104016-NSMCE2	Fusion	Unknown	Unknown	[12]