Fig. 3
From: Activation of NQO1 in NQO1*2 polymorphic human leukemic HL-60 cells by diet-derived sulforaphane
Induction of apoptosis by SFN as determined by changes in PARP cleavage, appearance of p-H2AX, decreases in pro-caspase 2 and pro-caspase 3. Western blot analysis revealed down regulation of PARP expression as evidenced by appearance of the 89-kDa PARP cleavage product, induction of p-H2AX, and down-regulation of both pro-caspase 2 and pro-caspase 3 in ≥ 10 μM, 48 h SFN treated cells